Parg poly (ADP-ribose) glycohydrolase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pargprovided by MGI
Official Full Name: poly (ADP-ribose) glycohydrolaseprovided by MGI
Primary source: MGI:MGI:1347094
See related: Ensembl:ENSMUSG00000021911 AllianceGenome:MGI:1347094
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables poly(ADP-ribose) glycohydrolase activity. Acts upstream of or within DNA damage response and detection of bacterium. Located in cytosol and nucleus. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Orthologous to human PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 3.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 19.4 cM; 14 B

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (31923900..32020671)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (32201930..32298714)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

O-GlcNAc has crosstalk with ADP-ribosylation via PARG.
Title: O-GlcNAc has crosstalk with ADP-ribosylation via PARG.
Dysfunction of poly (ADP-ribose) glycohydrolase suppresses osteoclast differentiation in RANKL-stimulated RAW264 cells.
Title: Dysfunction of poly (ADP-ribose) glycohydrolase suppresses osteoclast differentiation in RANKL-stimulated RAW264 cells.
Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase.
Title: Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase.
PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment.
Title: PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment.
Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis.
Title: Poly(ADP-ribose) glycohydrolase silencing-mediated H2B expression inhibits benzo(a)pyrene-induced carcinogenesis.
PPARgamma deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.
Title: PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.
the results of the present study imply that PARG could serve an important role in the growth of tumours and metastasis to the liver of colon carcinoma and may serve as a new target for clinical colon carcinoma therapy.
Title: PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF‑κB in tumour metastases of colon carcinoma.
This study contributes to the understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.
Title: Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.
PARG110 knockout retinal explants were highly resistant to cyclic GMP toxicity.
Title: Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.
we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.
Title: Expression of poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237156

BB318098 (e-PCR)
- UniSTS:209298

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables poly(ADP-ribose) glycohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(ADP-ribose) glycohydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables poly(ADP-ribose) glycohydrolase activity	ISO Inferred from Sequence Orthology more info
enables poly(ADP-ribose) glycohydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP generation from poly-ADP-D-ribose	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP generation from poly-ADP-D-ribose	ISO Inferred from Sequence Orthology more info
involved_in ATP generation from poly-ADP-D-ribose	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-sugar metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: poly(ADP-ribose) glycohydrolase

Names: cytosolic poly(ADP-ribose) glycohydrolase

NP_001346844.1

EC 3.2.1.143

NP_001361150.1

EC 3.2.1.143

NP_036090.2

EC 3.2.1.143

XP_030103682.1

EC 3.2.1.143

XP_030103683.1

EC 3.2.1.143

XP_036014496.1

EC 3.2.1.143

XP_036014497.1

EC 3.2.1.143

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359915.1 → NP_001346844.1 poly(ADP-ribose) glycohydrolase isoform 2

Status: VALIDATED

Source sequence(s)

AC167565, AI450246, AK080306, BC053037, BC059827

UniProtKB/Swiss-Prot

O88622, Q80YQ6, Q8CB72

Conserved Domains (1) summary

pfam05028
Location:491 → 816

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
NM_001374221.1 → NP_001361150.1 poly(ADP-ribose) glycohydrolase isoform 3

Status: VALIDATED

Source sequence(s)

AC154532, AC167565

UniProtKB/Swiss-Prot

O88622, Q80YQ6, Q8CB72

Conserved Domains (1) summary

pfam05028
Location:468 → 793

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
NM_011960.3 → NP_036090.2 poly(ADP-ribose) glycohydrolase isoform 1

See identical proteins and their annotated locations for NP_036090.2

Status: VALIDATED

Source sequence(s)

AC167565, AI450246, BC053037, BC059827

Consensus CDS

CCDS36865.1

UniProtKB/Swiss-Prot

O88622, Q80YQ6, Q8CB72

UniProtKB/TrEMBL

G3X8U8

Related

ENSMUSP00000022470.9, ENSMUST00000022470.15

Conserved Domains (1) summary

pfam05028
Location:574 → 902

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

31923900..32020671

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158604.1 → XP_036014497.1 poly(ADP-ribose) glycohydrolase isoform X3

UniProtKB/TrEMBL

A0A2I3BRU5

Related

ENSMUSP00000154704.2, ENSMUST00000164137.8

Conserved Domains (2) summary

pfam05028
Location:574 → 682

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

NF033845
Location:171 → 346

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_036158603.1 → XP_036014496.1 poly(ADP-ribose) glycohydrolase isoform X1

UniProtKB/Swiss-Prot

O88622, Q80YQ6, Q8CB72

Conserved Domains (1) summary

pfam05028
Location:491 → 816

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
XM_030247822.2 → XP_030103682.1 poly(ADP-ribose) glycohydrolase isoform X1

UniProtKB/Swiss-Prot

O88622, Q80YQ6, Q8CB72

Conserved Domains (1) summary

pfam05028
Location:491 → 816

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
XM_030247823.2 → XP_030103683.1 poly(ADP-ribose) glycohydrolase isoform X2

UniProtKB/Swiss-Prot

O88622, Q80YQ6, Q8CB72

Conserved Domains (1) summary

pfam05028
Location:468 → 793

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)