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    HGF hepatocyte growth factor [ Papio anubis (olive baboon) ]

    Gene ID: 101018541, updated on 8-Mar-2024

    Summary

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    Gene symbol
    HGF
    Gene description
    hepatocyte growth factor
    See related
    Ensembl:ENSPANG00000016786
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Papio anubis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Papio
    Orthologs
    human mouse all
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    Genomic context

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    See HGF in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    104 current Panubis1.0 (GCF_008728515.1) 4 NC_044979.1 (60597907..60668711, complement)
    103 previous assembly Panu_3.0 (GCF_000264685.3) 3 NC_018154.2 (120829164..120899989)

    Chromosome 4 - NC_044979.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110742879 Neighboring gene uncharacterized LOC116274500 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC110742878 Neighboring gene acyl-CoA desaturase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte growth factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Papio anubis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Panubis1.0 Primary Assembly

    Genomic

    1. NC_044979.1 Reference Panubis1.0 Primary Assembly

      Range
      60597907..60668711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009203538.4 → XP_009201802.2  hepatocyte growth factor isoform X3

      Conserved Domains (5) summary
      smart00130
      Location:191 → 268
      KR; Kringle domain
      cd00108
      Location:448 → 530
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:104 → 187
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:555 → 779
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:271 → 348
      Kringle; Kringle domain

    2. XM_009203537.4 → XP_009201801.2  hepatocyte growth factor isoform X2

      UniProtKB/TrEMBL
      A0A096MR85
      Related
      ENSPANP00000002280.2, ENSPANT00000005031.3
      Conserved Domains (5) summary
      smart00130
      Location:186 → 268
      KR; Kringle domain
      cd00108
      Location:448 → 530
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:99 → 182
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:555 → 779
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:271 → 348
      Kringle; Kringle domain

    3. XM_009203536.4 → XP_009201800.2  hepatocyte growth factor isoform X1

      Conserved Domains (5) summary
      smart00130
      Location:191 → 273
      KR; Kringle domain
      cd00108
      Location:453 → 535
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:104 → 187
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:560 → 784
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:276 → 353
      Kringle; Kringle domain

    4. XM_031665276.1 → XP_031521136.1  hepatocyte growth factor isoform X4

      Conserved Domains (5) summary
      smart00130
      Location:126 → 208
      KR; Kringle domain
      cd00108
      Location:388 → 470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39 → 122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:495 → 719
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:211 → 288
      Kringle; Kringle domain

    RNA

    1. XR_002521116.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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