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    Adgrb2 adhesion G protein-coupled receptor B2 [ Mus musculus (house mouse) ]

    Gene ID: 230775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrb2provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor B2provided by MGI
    Primary source
    MGI:MGI:2451244
    See related
    Ensembl:ENSMUSG00000028782 AllianceGenome:MGI:2451244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bai2
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within peripheral nervous system development and positive regulation of synapse assembly. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; spleen; and visual system. Orthologous to human ADGRB2 (adhesion G protein-coupled receptor B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 58.2), frontal lobe adult (RPKM 48.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrb2 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.43 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129878566..129916426)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129984773..130022633)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700003M07 gene Neighboring gene STARR-seq mESC enhancer starr_11515 Neighboring gene STARR-seq mESC enhancer starr_11516 Neighboring gene predicted gene, 54260 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129694658-129694811 Neighboring gene predicted gene 12963 Neighboring gene collagen, type XVI, alpha 1 Neighboring gene predicted gene, 46871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Speca DJ, et al. Mamm Genome, 2017 Dec. PMID 28894906, Free PMC Article
    2. A Synaptic Circuit Required for Acquisition but Not Recall of Social Transmission of Food Preference. Wang CY, et al. Neuron, 2020 Jul 8. PMID 32369733, Free PMC Article
    3. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. Jeong BC, et al. FEBS Lett, 2006 Jan 23. PMID 16412436
    4. Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma. Kee HJ, et al. FEBS Lett, 2004 Jul 2. PMID 15225653
    5. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. Kee HJ, et al. J Cereb Blood Flow Metab, 2002 Sep. PMID 12218411

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Surface expression of Bai2 R619W is markedly reduced relative to wild-type Bai2.
      Title: Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL.
    2. BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway
      Title: Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing.
    3. Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia.
      Title: Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcineurin-NFAT signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peripheral nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peripheral nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor B2
    Names
    G protein-coupled receptor brain-specific angiogenesis inhibitor 1
    brain-specific angiogenesis inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199696.2 → NP_001186625.1  adhesion G protein-coupled receptor B2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL626774
      Consensus CDS
      CCDS57300.1
      UniProtKB/TrEMBL
      H7BX92
      Related
      ENSMUSP00000112869.2, ENSMUST00000121049.8
      Conserved Domains (5) summary
      smart00303
      Location:809 → 862
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:467 → 531
      HormR; Domain present in hormone receptors
      smart00209
      Location:303 → 353
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:868 → 1137
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:551 → 708
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    2. NM_001290714.2 → NP_001277643.1  adhesion G protein-coupled receptor B2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL626774
      Consensus CDS
      CCDS71478.1
      UniProtKB/TrEMBL
      B1ASC0, H7BX92
      Related
      ENSMUSP00000112524.2, ENSMUST00000120204.8
      Conserved Domains (5) summary
      smart00303
      Location:809 → 862
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:467 → 531
      HormR; Domain present in hormone receptors
      smart00209
      Location:305 → 353
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:868 → 1104
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:551 → 708
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. NM_001290715.2 → NP_001277644.1  adhesion G protein-coupled receptor B2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277644.1

      Status: VALIDATED

      Source sequence(s)
      AL626774
      Consensus CDS
      CCDS80164.1
      UniProtKB/Swiss-Prot
      B1ASB7, B1ASB8, B2FDE3, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0, Q8CGM1
      UniProtKB/TrEMBL
      H7BWZ2
      Related
      ENSMUSP00000101636.3, ENSMUST00000106015.9
      Conserved Domains (5) summary
      smart00303
      Location:864 → 917
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:522 → 586
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:923 → 1192
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:606 → 763
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    4. NM_001377056.1 → NP_001363985.1  adhesion G protein-coupled receptor B2 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL626774
      UniProtKB/TrEMBL
      H7BX74
      Conserved Domains (6) summary
      smart00303
      Location:864 → 917
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:522 → 586
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      cd14964
      Location:925 → 950
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam16489
      Location:605 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:923 → 1180
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. NM_001377057.1 → NP_001363986.1  adhesion G protein-coupled receptor B2 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL626774
      UniProtKB/TrEMBL
      H7BX92
      Related
      ENSMUSP00000101639.3, ENSMUST00000106018.9
      Conserved Domains (6) summary
      smart00303
      Location:809 → 862
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:467 → 531
      HormR; Domain present in hormone receptors
      smart00209
      Location:303 → 353
      TSP1; Thrombospondin type 1 repeats
      cd14964
      Location:870 → 895
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam16489
      Location:550 → 705
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:868 → 1125
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. NM_001377058.1 → NP_001363987.1  adhesion G protein-coupled receptor B2 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL626774
      UniProtKB/TrEMBL
      H7BX92
      Conserved Domains (6) summary
      smart00303
      Location:809 → 862
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:467 → 531
      HormR; Domain present in hormone receptors
      smart00209
      Location:303 → 353
      TSP1; Thrombospondin type 1 repeats
      cd14964
      Location:870 → 895
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam16489
      Location:550 → 705
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:868 → 1125
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. NM_173071.4 → NP_775094.2  adhesion G protein-coupled receptor B2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_775094.2

      Status: VALIDATED

      Source sequence(s)
      AL626774
      Consensus CDS
      CCDS51309.1
      UniProtKB/TrEMBL
      H7BX74
      Related
      ENSMUSP00000101638.2, ENSMUST00000106017.8
      Conserved Domains (5) summary
      smart00303
      Location:864 → 917
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:522 → 586
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:923 → 1180
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:606 → 763
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129878566..129916426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240507.2 → XP_011238809.1  adhesion G protein-coupled receptor B2 isoform X2

      UniProtKB/TrEMBL
      H7BWZ2
      Conserved Domains (5) summary
      smart00303
      Location:864 → 917
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:522 → 586
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:923 → 1234
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:605 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    2. XM_030253457.1 → XP_030109317.1  adhesion G protein-coupled receptor B2 isoform X6

      UniProtKB/TrEMBL
      H7BWZ2
      Conserved Domains (5) summary
      smart00303
      Location:809 → 862
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:467 → 531
      HormR; Domain present in hormone receptors
      smart00209
      Location:305 → 353
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:868 → 1179
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:550 → 705
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. XM_030253456.1 → XP_030109316.1  adhesion G protein-coupled receptor B2 isoform X5

      UniProtKB/TrEMBL
      H7BX92
      Conserved Domains (5) summary
      smart00303
      Location:809 → 862
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:467 → 531
      HormR; Domain present in hormone receptors
      smart00209
      Location:303 → 353
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:868 → 1179
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:550 → 705
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    4. XM_030253459.1 → XP_030109319.1  adhesion G protein-coupled receptor B2 isoform X7

      UniProtKB/TrEMBL
      H7BX92
      Conserved Domains (5) summary
      smart00303
      Location:754 → 807
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:412 → 476
      HormR; Domain present in hormone receptors
      smart00209
      Location:359 → 409
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:813 → 1124
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:495 → 650
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    5. XM_036164059.1 → XP_036019952.1  adhesion G protein-coupled receptor B2 isoform X8

      UniProtKB/TrEMBL
      H7BX92
      Conserved Domains (6) summary
      smart00303
      Location:726 → 779
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:384 → 448
      HormR; Domain present in hormone receptors
      smart00209
      Location:331 → 381
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:785 → 1096
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:467 → 624
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      pfam19188
      Location:26 → 221
      AGRB_N; Adhesion GPCR B N-terminal region

    6. XM_011240506.1 → XP_011238808.1  adhesion G protein-coupled receptor B2 isoform X1

      UniProtKB/TrEMBL
      H7BWZ2
      Conserved Domains (5) summary
      smart00303
      Location:864 → 917
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:522 → 586
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:923 → 1234
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:605 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    7. XM_011240508.1 → XP_011238810.1  adhesion G protein-coupled receptor B2 isoform X3

      UniProtKB/TrEMBL
      H7BWZ2
      Related
      ENSMUSP00000030571.7, ENSMUST00000030571.7
      Conserved Domains (5) summary
      smart00303
      Location:864 → 917
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:522 → 586
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:923 → 1213
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:605 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    8. XM_011240512.1 → XP_011238814.1  adhesion G protein-coupled receptor B2 isoform X4

      UniProtKB/TrEMBL
      H7BX74
      Related
      ENSMUSP00000095480.4, ENSMUST00000097868.10
      Conserved Domains (6) summary
      smart00303
      Location:864 → 917
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:522 → 586
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      cd14964
      Location:925 → 950
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam16489
      Location:605 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:923 → 1180
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_004941876.1 RNA Sequence

    2. XR_004941877.1 RNA Sequence

    3. XR_004941874.1 RNA Sequence

    4. XR_004941875.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGM1.2 GenPept UniProtKB/Swiss-Prot:Q8CGM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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