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    klp-3 Kinesin-like protein;Kinesin-like protein klp-3 [ Caenorhabditis elegans ]

    Gene ID: 191697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klp-3
    Official Full Name
    Kinesin-like protein;Kinesin-like protein klp-3
    Primary source
    WormBase:WBGene00002216
    Locus tag
    CELE_T09A5.2
    See related
    AllianceGenome:WB:WBGene00002216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity. Involved in chromosome separation. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton. Is expressed in marginal cell. Orthologous to human KIFC3 (kinesin family member C3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klp-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (7842353..7845653)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acetylcholine receptor subunit alpha-type acr-7 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of the Caenorhabditis elegans klp-3, an ortholog of C terminus motor kinesins Kar3 and ncd. Khan ML, et al. J Mol Biol, 1997 Aug 1. PMID 9245592
    2. A novel C-terminal kinesin subfamily may be involved in chromosomal movement in caenorhabditis elegans. Ali MY, et al. FEBS Lett, 2000 Mar 17. PMID 10722848
    3. cDNA cloning and expression of a C-terminus motor kinesin-like protein KLP-17, involved in chromosomal movement in Caenorhabditis elegans. Ali MY, et al. Biochem Biophys Res Commun, 2000 Jan 19. PMID 10631116
    4. Metazoan motor models: kinesin superfamily in C. elegans. Siddiqui SS. Traffic, 2002 Jan. PMID 11872139
    5. Sorting and transport in C. elegans: aA model system with a sequenced genome. Koushika SP, et al. Curr Opin Cell Biol, 2000 Aug. PMID 10873821

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein;Kinesin-like protein klp-3
    NP_001022332.1
    • Confirmed by transcript evidence
    NP_001364641.1
    • Confirmed by transcript evidence
    NP_001364642.1
    • Confirmed by transcript evidence
    NP_001379016.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7842353..7845653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377823.1 → NP_001364642.1  Kinesin-like protein klp-3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      PRK03918
      Location:18 → 246
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01366
      Location:234 → 557
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. NM_001377824.1 → NP_001364641.1  Kinesin-like protein klp-3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd01366
      Location:226 → 549
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    3. NM_001393128.1 → NP_001379016.1  Kinesin-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MMP1
      Conserved Domains (1) summary
      cd01366
      Location:217 → 540
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    4. NM_001027161.4 → NP_001022332.1  Kinesin-like protein klp-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022332.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45962, Q7JMP3, Q7JMP4
      Conserved Domains (2) summary
      smart00129
      Location:245 → 569
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01366
      Location:243 → 566
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45962.1

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