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    Reep2 receptor accessory protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 225362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Reep2provided by MGI
    Official Full Name
    receptor accessory protein 2provided by MGI
    Primary source
    MGI:MGI:2385070
    See related
    Ensembl:ENSMUSG00000038555 AllianceGenome:MGI:2385070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables taste receptor binding activity. Involved in regulation of intracellular transport. Acts upstream of or within protein transport into membrane raft; sensory perception of bitter taste; and sensory perception of sweet taste. Located in endoplasmic reticulum membrane and plasma membrane. Is expressed in central nervous system; eye; ganglia; incisor; and testis. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 72A. Orthologous to human REEP2 (receptor accessory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 71.0), testis adult (RPKM 55.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Reep2 in Genome Data Viewer
    Location:
    18 B1; 18 18.75 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34973642..34980516)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34840589..34847463)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene microRNA 12191 Neighboring gene family with sequence similarity 53, member C Neighboring gene predicted gene 3561 Neighboring gene STARR-positive B cell enhancer ABC_E7576 Neighboring gene STARR-seq mESC enhancer starr_44212 Neighboring gene KDM3B lysine (K)-specific demethylase 3B Neighboring gene STARR-seq mESC enhancer starr_44215 Neighboring gene STARR-positive B cell enhancer ABC_E5650 Neighboring gene STARR-positive B cell enhancer ABC_E8958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35020809-35020992 Neighboring gene early growth response 1 Neighboring gene predicted gene, 54018

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. Björk S, et al. PLoS One, 2013. PMID 24098485, Free PMC Article
    2. REEP2 enhances sweet receptor function by recruitment to lipid rafts. Ilegems E, et al. J Neurosci, 2010 Oct 13. PMID 20943918, Free PMC Article
    3. Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development. Zhou J, et al. Hum Mol Genet, 2023 Aug 7. PMID 37228035, Free PMC Article
    4. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249
    5. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28827

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables taste receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables taste receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein transport into membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of intracellular transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of bitter taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sweet taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor expression-enhancing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204914.1 → NP_001191843.1  receptor expression-enhancing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001191843.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BB709634, BC020184, CX216997, EU555417
      UniProtKB/TrEMBL
      C1IE02
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    2. NM_144865.2 → NP_659114.2  receptor expression-enhancing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_659114.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB709634, BC020184, CX216997
      Consensus CDS
      CCDS29135.1
      UniProtKB/Swiss-Prot
      Q8VCD6
      Related
      ENSMUSP00000036065.8, ENSMUST00000043484.8
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34973642..34980516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCD6.2 GenPept UniProtKB/Swiss-Prot:Q8VCD6

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