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    Dmxl1 Dmx-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 240283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmxl1provided by MGI
    Official Full Name
    Dmx-like 1provided by MGI
    Primary source
    MGI:MGI:2443926
    See related
    Ensembl:ENSMUSG00000037416 AllianceGenome:MGI:2443926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030030C22; C630007L23Rik
    Summary
    Predicted to be involved in vacuolar acidification. Predicted to be part of RAVE complex. Orthologous to human DMXL1 (Dmx like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.7), cerebellum adult (RPKM 3.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dmxl1 in Genome Data Viewer
    Location:
    18 D1; 18 27.12 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (49965657..50098540)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (49832590..49965473)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700065O20 gene Neighboring gene predicted gene, 57648 Neighboring gene STARR-seq mESC enhancer starr_44570 Neighboring gene STARR-seq mESC enhancer starr_44572 Neighboring gene STARR-positive B cell enhancer ABC_E1957 Neighboring gene tumor necrosis factor, alpha-induced protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E7584 Neighboring gene STARR-positive B cell enhancer ABC_E8716 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:50183799-50183908 Neighboring gene STARR-positive B cell enhancer ABC_E4248 Neighboring gene predicted gene, 33335 Neighboring gene RIKEN cDNA C030005K06 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation. Merkulova M, et al. Sci Rep, 2015 Oct 7. PMID 26442671, Free PMC Article
    2. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RAVE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dmX-like protein 1
    Names
    X-like 1 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081371.2 → NP_001074840.2  dmX-like protein 1

      See identical proteins and their annotated locations for NP_001074840.2

      Status: VALIDATED

      Source sequence(s)
      AC113451, AC166570, AEKQ02092752
      Consensus CDS
      CCDS37816.2
      UniProtKB/Swiss-Prot
      Q3TLG8, Q6PHM6, Q6PNC0, Q8BQF2
      UniProtKB/TrEMBL
      F8WGX5
      Related
      ENSMUSP00000137871.2, ENSMUST00000180611.8
      Conserved Domains (4) summary
      COG2319
      Location:2766 → 3008
      WD40; WD40 repeat [General function prediction only]
      pfam12234
      Location:1139 → 1875
      Rav1p_C; RAVE protein 1 C terminal
      sd00039
      Location:2777 → 2822
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:2733 → 2990
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      49965657..50098540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525916.4 → XP_006525979.1  dmX-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F8WGX5
      Conserved Domains (3) summary
      sd00039
      Location:2836 → 2881
      7WD40; WD40 repeat [structural motif]
      pfam12234
      Location:1139 → 1875
      Rav1p_C; RAVE protein 1 C terminal
      cl29593
      Location:2792 → 3049
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006525917.4 → XP_006525980.1  dmX-like protein 1 isoform X2

      UniProtKB/TrEMBL
      F8WGX5
      Conserved Domains (3) summary
      sd00039
      Location:2815 → 2860
      7WD40; WD40 repeat [structural motif]
      pfam12234
      Location:1139 → 1875
      Rav1p_C; RAVE protein 1 C terminal
      cl29593
      Location:2771 → 3028
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006525918.4 → XP_006525981.1  dmX-like protein 1 isoform X3

      UniProtKB/TrEMBL
      F8WGX5
      Conserved Domains (3) summary
      sd00039
      Location:2798 → 2843
      7WD40; WD40 repeat [structural motif]
      pfam12234
      Location:1139 → 1875
      Rav1p_C; RAVE protein 1 C terminal
      cl29593
      Location:2754 → 3011
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_030250455.1 → XP_030106315.1  dmX-like protein 1 isoform X4

      UniProtKB/TrEMBL
      F8WGX5
      Conserved Domains (3) summary
      sd00039
      Location:2679 → 2724
      7WD40; WD40 repeat [structural motif]
      pfam12234
      Location:982 → 1718
      Rav1p_C; RAVE protein 1 C terminal
      cl29593
      Location:2635 → 2892
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PNC0.1 GenPept UniProtKB/Swiss-Prot:Q6PNC0

    Gene LinkOut

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