Sephs2 selenophosphate synthetase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sephs2provided by MGI
Official Full Name: selenophosphate synthetase 2provided by MGI
Primary source: MGI:MGI:108388
See related: Ensembl:ENSMUSG00000049091 AllianceGenome:MGI:108388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sps2; Ysg3
Summary: This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017]
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.43 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126871051..126873231, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127271879..127274059, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These in vivo studies indicate that SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals.
Title: Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables selenide, water dikinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables selenide, water dikinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within selenium compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within selenium compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in selenocysteine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within selenocysteine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: selenide, water dikinase 2

Names: selenium donor protein 2; selenophosphate synthase 2; the SelD gene product

NP_033292.2

EC 2.7.9.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009266.3 → NP_033292.2 selenide, water dikinase 2

See identical proteins and their annotated locations for NP_033292.2

Status: REVIEWED

Source sequence(s)

AK149516, AK168722, U43285

Consensus CDS

CCDS21863.1

UniProtKB/Swiss-Prot

P97364, Q3TGI4, Q80ZY9

Related

ENSMUSP00000081009.5, ENSMUST00000082428.6

Conserved Domains (2) summary

cd02195
Location:54 → 410

SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...

TIGR00476
Location:53 → 386

selD; selenium donor protein