Rpl11 ribosomal protein L11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpl11provided by MGI
Official Full Name: ribosomal protein L11provided by MGI
Primary source: MGI:MGI:1914275
See related: Ensembl:ENSMUSG00000059291 AllianceGenome:MGI:1914275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010203J19Rik
Summary: A structural constituent of ribosome. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of signal transduction by p53 class mediator; and protein localization to nucleus. Located in cytoplasm and nucleolus. Part of cytosolic large ribosomal subunit. Is expressed in cerebral cortex. Used to study Diamond-Blackfan anemia 7. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 384.9), liver E14 (RPKM 303.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 68.34 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135776665..135780704, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136049354..136053393, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway.
Title: Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway.
Single-cell analysis of erythropoiesis in Rpl11 haploinsufficient mice reveals insight into the pathogenesis of Diamond-Blackfan anemia.
Title: Single-cell analysis of erythropoiesis in Rpl11 haploinsufficient mice reveals insight into the pathogenesis of Diamond-Blackfan anemia.
there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 axis which is important in normal hematopoiesis.
Title: Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis.
Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.
Title: Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.
The association of the L11 and Mdm2 is resulted the activation of the pathway in embryonic stem cells.
Title: Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5S rRNA binding	IEA Inferred from Electronic Annotation more info
enables 5S rRNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables ubiquitin ligase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein neddylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
involved_in protein targeting	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	IPI Inferred from Physical Interaction more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large ribosomal subunit protein uL5

Names: 60S ribosomal protein L11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025919.3 → NP_080195.1 large ribosomal subunit protein uL5

See identical proteins and their annotated locations for NP_080195.1

Status: VALIDATED

Source sequence(s)

AK008422, BP770399, BX530725, CA321948

Consensus CDS

CCDS18799.1

UniProtKB/Swiss-Prot

Q3TPE3, Q6ZWY0, Q9CXW4

UniProtKB/TrEMBL

A2BH06

Related

ENSMUSP00000099595.5, ENSMUST00000102536.11

Conserved Domains (1) summary

PTZ00156
Location:5 → 175

PTZ00156; 60S ribosomal protein L11; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

135776665..135780704 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539112.3 → XP_006539175.1 large ribosomal subunit protein uL5 isoform X1

UniProtKB/TrEMBL

A2BH06

Related

ENSMUSP00000121108.2, ENSMUST00000155873.3

Conserved Domains (1) summary

PTZ00156
Location:8 → 178

PTZ00156; 60S ribosomal protein L11; Provisional