Rab3a RAB3A, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab3aprovided by MGI
Official Full Name: RAB3A, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:97843
See related: Ensembl:ENSMUSG00000031840 AllianceGenome:MGI:97843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTP-dependent protein binding activity and protein-macromolecule adaptor activity. Involved in several processes, including modulation of chemical synaptic transmission; secretion by cell; and synaptic vesicle clustering. Acts upstream of or within several processes, including chemical synaptic transmission; maintenance of presynaptic active zone structure; and synaptic vesicle maturation. Located in several cellular components, including cytoplasmic vesicle; presynaptic active zone; and terminal bouton. Is active in synaptic vesicle membrane. Is expressed in brain and inner ear. Orthologous to human RAB3A (RAB3A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 223.6), cortex adult (RPKM 207.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71207258..71211276)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70754703..70758608)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein.
Title: Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein.
TET3-mediated accumulation of DNA hydroxymethylation contributes to the activity-dependent gene expression of Rab3a in post-mitotic neurons.
Title: TET3-mediated accumulation of DNA hydroxymethylation contributes to the activity-dependent gene expression of Rab3a in post-mitotic neurons.
Rab3A might function as a marker of cortical granules and participates in cortical granule exocytosis in mouse eggs.
Title: Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs.
Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells.
Title: Rab3a promotes brain tumor initiation and progression.
Rab3a deficiency promotes constitutive secretion and underlies selective impairment of Ca(2)-dependent release of alpha-MSH
Title: Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis.
Rab3a deletion restores excitatory/inhibitory imbalance in synapsin II(-) hippocampal slices.
Title: Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus.
betaARs couple to a cAMP/Epac/PLC/Munc13-1/Rab3a/RIM1a-dependent pathway to enhance glutamate release at cerebrocortical nerve terminals.
Title: β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.
key role of Rab3a proteins control the balance between secretory vesicle biogenesis and degradation, and suggest that the ablation of this protein probably changes the nature of the reservoir of secretory vesicles available for regulated exocytosis.
Title: Rab3a ablation related changes in morphology of secretory vesicles in major endocrine pancreatic cells, pituitary melanotroph cells and adrenal gland chromaffin cells in mice.
alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity
Title: α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.
Data show diminished actin plasticity in the cell processes of Rab3A knockout (KO) podocytes.
Title: Proteinuria and glomerular damage in Rab3A knockout mice chronically fed a high-glucose diet.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X72966 (e-PCR)
- UniSTS:185762

RH133798 (e-PCR)
- UniSTS:217081

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables GDP-dissociation inhibitor binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin V binding	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acrosomal vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in acrosomal vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-ion regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of localization in cell	IPI Inferred from Physical Interaction more info	PubMed
involved_in evoked neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of presynaptic active zone structure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane repair	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulated secretory pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of regulated secretory pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of long-term synaptic potentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of plasma membrane repair	IEA Inferred from Electronic Annotation more info
involved_in regulation of plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic dense core granule exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to electrical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synaptic vesicle maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle transport	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-sculpted glutamate transport vesicle membrane	TAS Traceable Author Statement more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166399.3 → NP_001159871.1 ras-related protein Rab-3A

See identical proteins and their annotated locations for NP_001159871.1

Status: VALIDATED

Source sequence(s)

CAAA01070179

Consensus CDS

CCDS22379.1

UniProtKB/Swiss-Prot

P05713, P63011, Q3TSL4

UniProtKB/TrEMBL

Q0PD63

Related

ENSMUSP00000105720.3, ENSMUST00000110093.9

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
NM_001328047.2 → NP_001314976.1 ras-related protein Rab-3A

Status: VALIDATED

Source sequence(s)

CAAA01070179

Consensus CDS

CCDS22379.1

UniProtKB/Swiss-Prot

P05713, P63011, Q3TSL4

UniProtKB/TrEMBL

Q0PD63

Related

ENSMUSP00000105717.2, ENSMUST00000110090.8

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
NM_001378892.1 → NP_001365821.1 ras-related protein Rab-3A

Status: VALIDATED

Source sequence(s)

CAAA01070179

UniProtKB/Swiss-Prot

P05713, P63011, Q3TSL4

UniProtKB/TrEMBL

Q0PD63

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
NM_001378893.1 → NP_001365822.1 ras-related protein Rab-3A

Status: VALIDATED

Source sequence(s)

CAAA01070179

UniProtKB/Swiss-Prot

P05713, P63011, Q3TSL4

UniProtKB/TrEMBL

Q0PD63

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
NM_009001.7 → NP_033027.1 ras-related protein Rab-3A

See identical proteins and their annotated locations for NP_033027.1

Status: VALIDATED

Source sequence(s)

CAAA01070179

Consensus CDS

CCDS22379.1

UniProtKB/Swiss-Prot

P05713, P63011, Q3TSL4

UniProtKB/TrEMBL

Q0PD63

Related

ENSMUSP00000034301.6, ENSMUST00000034301.12

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71207258..71211276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153836.1 → XP_036009729.1 ras-related protein Rab-3A isoform X1

UniProtKB/Swiss-Prot

P05713, P63011, Q3TSL4

UniProtKB/TrEMBL

Q0PD63

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D