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    Serpinb6c serine (or cysteine) peptidase inhibitor, clade B, member 6c [ Mus musculus (house mouse) ]

    Gene ID: 97848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpinb6cprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6cprovided by MGI
    Primary source
    MGI:MGI:2145481
    See related
    Ensembl:ENSMUSG00000052180 AllianceGenome:MGI:2145481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPIC; SPI3C; ovalbumin
    Summary
    Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Is expressed in esophagus epithelium; ovary; ovary follicle; and testis. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Serpinb6c in Genome Data Viewer
    Location:
    13 A3.3; 13 13.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34063799..34089709, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33879816..33905726, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 94 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6e Neighboring gene STARR-seq mESC enhancer starr_34130 Neighboring gene STARR-seq mESC enhancer starr_34131 Neighboring gene STARR-seq mESC enhancer starr_34132 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene RIKEN cDNA 1110046J04 gene Neighboring gene N-ribosyldihydronicotinamide quinone reductase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of serpinb6 serpins in germ and somatic cells of mouse gonads. Charron Y, et al. Mol Reprod Dev, 2006 Jan. PMID 16175637
    2. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
    3. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365
    4. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine protease inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine proteinase inhibitor member 6C
    Names
    serine (or cysteine) proteinase inhibitor, clade B, member 6c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382852.1 → NP_001369781.1  serine proteinase inhibitor member 6C

      Status: VALIDATED

      Source sequence(s)
      AL450406
      UniProtKB/TrEMBL
      Q6P6K7, W4VSP4
      Related
      ENSMUSP00000105902.3, ENSMUST00000110273.9
      Conserved Domains (1) summary
      cl38926
      Location:2 → 379
      serpin; SERine Proteinase INhibitors (serpin) family

    2. NM_148942.3 → NP_683744.2  serine proteinase inhibitor member 6C

      See identical proteins and their annotated locations for NP_683744.2

      Status: VALIDATED

      Source sequence(s)
      AL450406, BC062169
      Consensus CDS
      CCDS49227.1
      UniProtKB/TrEMBL
      Q6P6K7, W4VSP4
      Related
      ENSMUSP00000127619.2, ENSMUST00000172184.2
      Conserved Domains (1) summary
      cl38926
      Location:2 → 379
      serpin; SERine Proteinase INhibitors (serpin) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      34063799..34089709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158233.1 → XP_036014126.1  serine proteinase inhibitor member 6C isoform X1

      UniProtKB/TrEMBL
      Q6P6K7
      Conserved Domains (1) summary
      cl38926
      Location:24 → 346
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version

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