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    Susd4 sushi domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 96935, updated on 27-Nov-2024

    Summary

    Official Symbol
    Susd4provided by MGI
    Official Full Name
    sushi domain containing 4provided by MGI
    Primary source
    MGI:MGI:2138351
    See related
    Ensembl:ENSMUSG00000038576 AllianceGenome:MGI:2138351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430021N18Rik
    Summary
    Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Is expressed in brain and cortical plate. Orthologous to human SUSD4 (sushi domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 29.8), cortex adult (RPKM 26.8) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Susd4 in Genome Data Viewer
    Location:
    1 H5; 1 85.94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182591609..182724161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (182764044..182896596)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene calpain 8 Neighboring gene coiled-coil domain containing 185 Neighboring gene STARR-seq mESC enhancer starr_03290 Neighboring gene STARR-seq mESC enhancer starr_03291 Neighboring gene STARR-seq mESC enhancer starr_03292 Neighboring gene STARR-seq mESC enhancer starr_03293 Neighboring gene STARR-seq mESC enhancer starr_03294 Neighboring gene toll-like receptor 5 Neighboring gene predicted gene, 33747

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC30368

    General protein information

    Preferred Names
    sushi domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356461.1NP_001343390.1  sushi domain-containing protein 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Consensus CDS
      CCDS15590.1
      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Related
      ENSMUSP00000119488.2, ENSMUST00000153348.8
      Conserved Domains (2) summary
      smart00032
      Location:243297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57238
      PHA02927; secreted complement-binding protein; Provisional
    2. NM_001356462.1NP_001343391.1  sushi domain-containing protein 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Consensus CDS
      CCDS15590.1
      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Conserved Domains (2) summary
      smart00032
      Location:243297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57238
      PHA02927; secreted complement-binding protein; Provisional
    3. NM_001356463.1NP_001343392.1  sushi domain-containing protein 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Conserved Domains (2) summary
      smart00032
      Location:245299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57238
      PHA02927; secreted complement-binding protein; Provisional
    4. NM_001356464.1NP_001343393.1  sushi domain-containing protein 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Conserved Domains (2) summary
      smart00032
      Location:245299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57238
      PHA02927; secreted complement-binding protein; Provisional
    5. NM_144796.5NP_659045.2  sushi domain-containing protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_659045.2

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Consensus CDS
      CCDS15590.1
      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Related
      ENSMUSP00000082873.4, ENSMUST00000085724.5
      Conserved Domains (2) summary
      smart00032
      Location:243297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57238
      PHA02927; secreted complement-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      182591609..182724161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243824.2XP_030099684.1  sushi domain-containing protein 4 isoform X3

      Conserved Domains (2) summary
      cd00033
      Location:81138
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:35197
      PHA02927; secreted complement-binding protein; Provisional
    2. XM_030243823.1XP_030099683.1  sushi domain-containing protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Conserved Domains (2) summary
      smart00032
      Location:243297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57238
      PHA02927; secreted complement-binding protein; Provisional
    3. XM_006497063.2XP_006497126.1  sushi domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006497126.1

      UniProtKB/Swiss-Prot
      Q8BH32
      Conserved Domains (2) summary
      smart00032
      Location:245299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57238
      PHA02927; secreted complement-binding protein; Provisional