snpc-4 snRNA-activating protein complex subunit 4 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: snpc-4
Official Full Name: snRNA-activating protein complex subunit 4 homolog
Primary source: WormBase:WBGene00001568
Locus tag: CELE_F32H2.1
See related: AllianceGenome:WB:WBGene00001568
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in protein folding. Predicted to be located in nucleus. Predicted to be part of snRNA-activating protein complex. Is expressed in germ cell; germ line; head neurons; intestine; and somatic gonad. Orthologous to human SNAPC4 (small nuclear RNA activating complex polypeptide 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See snpc-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (8962322..8966129)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNPC-4 binding establishes a positive expression environment across piRNA domains, providing an explanation for the conserved clustering of individually transcribed piRNA genes.
Title: The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally required for piRNA abundance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32H2.1 (e-PCR)
- UniSTS:317482

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in snRNA transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of snRNA-activating protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: snRNA-activating protein complex subunit 4 homolog

NP_492411.1

Partially confirmed by transcript evidence

NP_492412.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8962322..8966129

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060011.5 → NP_492412.1 snRNA-activating protein complex subunit 4 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492412.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91868

Conserved Domains (4) summary

smart00717
Location:357 → 404

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:411 → 455

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:356 → 402

Myb_DNA-binding; Myb-like DNA-binding domain

cl21498
Location:219 → 261

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_060010.6 → NP_492411.1 snRNA-activating protein complex subunit 4 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492411.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62208, P91868

Conserved Domains (4) summary

smart00717
Location:357 → 404

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:411 → 455

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:356 → 402

Myb_DNA-binding; Myb-like DNA-binding domain

cl21498
Location:219 → 261

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...