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    nhr-85 Nuclear hormone receptor family member nhr-85 [ Caenorhabditis elegans ]

    Gene ID: 191732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-85
    Official Full Name
    Nuclear hormone receptor family member nhr-85
    Primary source
    WormBase:WBGene00003675
    Locus tag
    CELE_W05B5.3
    See related
    AllianceGenome:WB:WBGene00003675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in excretory duct cell; hypodermis; vulva; and vulval precursor cell. Human ortholog(s) of this gene implicated in brain small vessel disease and type 2 diabetes mellitus. Orthologous to several human genes including NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-85 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (13055201..13062122, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Calcium-transporting ATPase Neighboring gene Uncharacterized protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene PAN-3 domain-containing protein Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An nhr-85::GFP::AID*::3xFLAG knock-in allele for investigation of molting and oscillatory gene regulation. Myles KM, et al. MicroPubl Biol, 2023. PMID 37927911, Free PMC Article
    2. A circadian-like gene network programs the timing and dosage of heterochronic miRNA transcription during C. elegans development. Kinney B, et al. Dev Cell, 2023 Nov 20. PMID 37643611, Free PMC Article
    3. Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans. Hiroki S, et al. Commun Biol, 2024 Feb 28. PMID 38418700, Free PMC Article
    4. Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans. Gissendanner CR, et al. Dev Biol, 2004 Feb 15. PMID 14738886
    5. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-85
    NP_001021667.1
    • Confirmed by transcript evidence
    NP_001021668.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13055201..13062122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026496.3 → NP_001021667.1  Nuclear hormone receptor family member nhr-85 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021667.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6BER3, Q9XUK7
      Conserved Domains (2) summary
      cd07166
      Location:110 → 196
      NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
      smart00430
      Location:261 → 369
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001026497.4 → NP_001021668.1  Nuclear hormone receptor family member nhr-85 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XUK7
      Conserved Domains (2) summary
      cl02596
      Location:1 → 18
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:83 → 191
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUK7.2

    Gene LinkOut

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