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    rev-3 DNA polymerase [ Caenorhabditis elegans ]

    Gene ID: 175809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rev-3
    Official Full Name
    DNA polymerase
    Primary source
    WormBase:WBGene00021344
    Locus tag
    CELE_Y37B11A.2
    See related
    AllianceGenome:WB:WBGene00021344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and nucleotide binding activity. Predicted to be involved in DNA replication and translesion synthesis. Predicted to be part of zeta DNA polymerase complex. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rev-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (5774679..5790650, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Receptor-type tyrosine-protein phosphatase-like ida-1 Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene VWFA domain-containing protein;von Willebrand factor type A domain protein Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Citrate transport protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA polymerase theta Neighboring gene Homeobox protein ceh-10 Neighboring gene Kinetochore protein Nuf2 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combined loss of three DNA damage response pathways renders C. elegans intolerant to light. van Bostelen I, et al. DNA Repair (Amst), 2017 Jun. PMID 28472716
    2. Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos. Holway AH, et al. J Cell Biol, 2006 Mar 27. PMID 16549501, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translesion synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase
    NP_001299851.1
    • Confirmed by transcript evidence
    NP_001299902.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5774679..5790650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001312922.3 → NP_001299851.1  DNA polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUS7
      Conserved Domains (3) summary
      cd05534
      Location:752 → 1201
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam00136
      Location:752 → 1193
      DNA_pol_B; DNA polymerase family B
      cl10012
      Location:517 → 725
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    2. NM_001312973.3 → NP_001299902.1  DNA polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX87
      Conserved Domains (3) summary
      cd05778
      Location:233 → 441
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:468 → 917
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam00136
      Location:468 → 909
      DNA_pol_B; DNA polymerase family B
    Nucleotide Protein
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