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    parg-1 Poly(ADP-ribose) glycohydrolase 1;poly(ADP-ribose) glycohydrolase [ Caenorhabditis elegans ]

    Gene ID: 177683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    parg-1
    Official Full Name
    Poly(ADP-ribose) glycohydrolase 1;poly(ADP-ribose) glycohydrolase
    Primary source
    WormBase:WBGene00004051
    Locus tag
    CELE_F20C5.1
    See related
    AllianceGenome:WB:WBGene00004051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in neuron projection and nucleus. Is expressed in anal depressor muscle; body wall musculature; intestine; nervous system; and pharynx. Orthologous to human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See parg-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (8746252..8752676)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Signal recognition particle 54 kDa protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Enlarged germline granules protein 1 Neighboring gene Uncharacterized protein Neighboring gene Kinesin-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans. Nicolai MM, et al. Int J Mol Sci, 2021 Oct 9. PMID 34681565, Free PMC Article
    2. Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity. Janisiw E, et al. Nat Commun, 2020 Sep 25. PMID 32978394, Free PMC Article
    3. Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression. St-Laurent JF, et al. DNA Repair (Amst), 2007 Mar 1. PMID 17188026
    4. Poly(ADP-ribose) metabolism analysis in the nematode Caenorhabditis elegans. St-Laurent JF, et al. Methods Mol Biol, 2011. PMID 21870275
    5. The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. Gagnon SN, et al. Biochem J, 2002 Nov 15. PMID 12145714, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
      Title: PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
    2. Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans.
      Title: Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans.
    3. Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity.
      Title: Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity.
    4. cloning of poly(ADP-ribose) glycohydrolases (pme-3).
      Title: Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(ADP-ribose) glycohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleotide-sugar metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-sugar metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-sugar metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Poly(ADP-ribose) glycohydrolase 1;poly(ADP-ribose) glycohydrolase
    NP_001023135.1
    • Confirmed by transcript evidence
    NP_001023136.1
    • Confirmed by transcript evidence
    NP_001122772.1
    • Confirmed by transcript evidence
    NP_001255324.1
    • Confirmed by transcript evidence
    NP_001263754.1
    • Confirmed by transcript evidence
    NP_001294060.1
    • Confirmed by transcript evidence
    NP_001294061.1
    • Confirmed by transcript evidence
    NP_001294062.1
    • Confirmed by transcript evidence
    NP_001367109.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8746252..8752676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307133.3 → NP_001294062.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LVA3
      Conserved Domains (1) summary
      pfam05028
      Location:401 → 718
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    2. NM_001276825.3 → NP_001263754.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8EC33
      Conserved Domains (1) summary
      pfam05028
      Location:399 → 718
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    3. NM_001027965.4 → NP_001023136.1  Poly(ADP-ribose) glycohydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023136.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q867X0
      Conserved Domains (1) summary
      pfam05028
      Location:381 → 700
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    4. NM_001307132.3 → NP_001294061.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M907
      Conserved Domains (2) summary
      COG5271
      Location:84 → 278
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam05028
      Location:396 → 713
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    5. NM_001027964.5 → NP_001023135.1  Poly(ADP-ribose) glycohydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19637, Q867X0
      Conserved Domains (1) summary
      pfam05028
      Location:398 → 717
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    6. NM_001307131.4 → NP_001294060.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M5W8
      Conserved Domains (1) summary
      pfam05028
      Location:378 → 695
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    7. NM_001129300.4 → NP_001122772.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYS4
      Conserved Domains (1) summary
      pfam05028
      Location:398 → 694
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    8. NM_001380380.2 → NP_001367109.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRP7

    9. NM_001268395.3 → NP_001255324.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GU97
      Conserved Domains (1) summary
      pfam05028
      Location:221 → 540
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q867X0.1

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