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    pyp-1 Inorganic pyrophosphatase 1 [ Caenorhabditis elegans ]

    Gene ID: 177856, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pyp-1
    Official Full Name
    Inorganic pyrophosphatase 1
    Primary source
    WormBase:WBGene00008149
    Locus tag
    CELE_C47E12.4
    See related
    AllianceGenome:WB:WBGene00008149
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inorganic diphosphate phosphatase activity. Involved in innate immune response. Located in neuron projection and vacuole. Is expressed in coelomocyte; intestine; and neurons. Orthologous to human PPA1 (inorganic pyrophosphatase 1) and PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pyp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (9995385..9998925, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E1 ubiquitin-activating enzyme Neighboring gene alpha-1,2-Mannosidase Neighboring gene ADP/ATP translocase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans. Ko KM, et al. FEBS Lett, 2007 Nov 27. PMID 17981157
    2. Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans. Mádi A, et al. Biochim Biophys Acta, 2008 Nov. PMID 18620082
    3. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. Gaiser AM, et al. J Mol Biol, 2009 Aug 21. PMID 19559711
    4. C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Andersen EC, et al. Development, 2006 Jul. PMID 16774993
    5. Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response. Quach TK, et al. PLoS One, 2013. PMID 23533643, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. larval arrest phenotype was successfully rescued by reintroduction of the pyp-1 gene
      Title: PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inorganic diphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in phosphate-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Inorganic pyrophosphatase 1
    NP_001023073.1
    • Confirmed by transcript evidence
    NP_001023075.2
    • Partially confirmed by transcript evidence
    NP_001023076.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9995385..9998925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027904.7 → NP_001023075.2  Inorganic pyrophosphatase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023075.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18680, Q86DB1, Q86DB2, Q86DB3
      Conserved Domains (1) summary
      cl00217
      Location:119 → 375
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    2. NM_001027902.4 → NP_001023073.1  Inorganic pyrophosphatase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18680
      Conserved Domains (1) summary
      cl00217
      Location:25 → 286
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    3. NM_001027905.7 → NP_001023076.1  Inorganic pyrophosphatase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18680
      Conserved Domains (1) summary
      cl00217
      Location:2 → 240
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18680.5

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