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    rbd-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rbd-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00004315
    Locus tag
    CELE_T23F6.4
    See related
    AllianceGenome:WB:WBGene00004315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including collagen and cuticulin-based cuticle development; positive regulation of growth rate; and vulval development. Located in nucleolus. Orthologous to human RBM19 (RNA binding motif protein 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rbd-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (12724986..12730095)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Intrinsically Disordered Protein, expressed in Pharynx Neighboring gene NIDO domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene pseudo Neighboring gene MAM domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing. Saijou E, et al. Nucleic Acids Res, 2004. PMID 14872060, Free PMC Article
    2. A novel conserved RNA-binding domain protein, RBD-1, is essential for ribosome biogenesis. Björk P, et al. Mol Biol Cell, 2002 Oct. PMID 12388766, Free PMC Article
    3. Evaluation and identification of reliable reference genes for toxicological study in Caenorhabditis elegans. Wu H, et al. Mol Biol Rep, 2014 May. PMID 24510408
    4. Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Voutev R, et al. Dev Biol, 2006 Oct 1. PMID 16876152
    5. Selection of reliable reference genes in Caenorhabditis elegans for analysis of nanotoxicity. Zhang Y, et al. PLoS One, 2012. PMID 22438870, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that RBD-1 plays a role in structurally coordinating pre-rRNA during ribosome biogenesis and that this function is conserved in all eukaryotes.
      Title: A novel conserved RNA-binding domain protein, RBD-1, is essential for ribosome biogenesis.
    2. RBD-1 is essential for 18S ribosomal RNA processing during Caenorhabditis elegans early development.
      Title: RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001293920.1
    • Confirmed by transcript evidence
    NP_502432.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12724986..12730095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070031.6 → NP_502432.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502432.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XU67
      Conserved Domains (7) summary
      cd12317
      Location:483 → 555
      RRM4_RBM19_RRM3_MRD1; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and RNA recognition motif 3 in multiple RNA-binding domain-containing protein 1 (MRD1)
      cd12318
      Location:641 → 724
      RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
      cd12564
      Location:3 → 78
      RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12566
      Location:277 → 355
      RRM2_MRD1; RNA recognition motif 2 in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins
      cd12571
      Location:748 → 826
      RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
      TIGR01661
      Location:3 → 352
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:180 → 236
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001306991.3 → NP_001293920.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJ27
      Conserved Domains (3) summary
      cd12317
      Location:1 → 71
      RRM4_RBM19_RRM3_MRD1; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and RNA recognition motif 3 in multiple RNA-binding domain-containing protein 1 (MRD1)
      cd12318
      Location:157 → 240
      RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
      cd12571
      Location:264 → 342
      RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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