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    rad-54.B DNA repair and recombination protein RAD54-like [ Caenorhabditis elegans ]

    Gene ID: 190999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rad-54.B
    Official Full Name
    DNA repair and recombination protein RAD54-like
    Primary source
    WormBase:WBGene00013792
    Locus tag
    CELE_Y116A8C.13
    See related
    AllianceGenome:WB:WBGene00013792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA translocase activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rad-54.B in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (16950067..16962868)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ABC2_membrane domain-containing protein;Transmembrane protein 185B Neighboring gene ADP-ribosylation factor 6 Neighboring gene Peptidase S54 rhomboid domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells. Yamaya K, et al. Nucleic Acids Res, 2023 Sep 22. PMID 37548405, Free PMC Article
    2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells.
      Title: Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair and recombination protein RAD54-like
    NP_001255913.1
    • Confirmed by transcript evidence
    NP_001255914.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16950067..16962868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268984.2 → NP_001255913.1  DNA repair and recombination protein RAD54-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2S8
      Conserved Domains (3) summary
      cd00046
      Location:235 → 374
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:209 → 480
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:516 → 631
      Helicase_C; Helicase conserved C-terminal domain

    2. NM_001268985.3 → NP_001255914.1  DNA repair and recombination protein RAD54-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQA7
      Conserved Domains (3) summary
      cd00046
      Location:122 → 261
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:96 → 367
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:403 → 518
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
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