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    srp-7 Serpin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srp-7
    Official Full Name
    Serpin domain-containing protein
    Primary source
    WormBase:WBGene00005648
    Locus tag
    CELE_F20D6.4
    See related
    AllianceGenome:WB:WBGene00005648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; Nagashima-type palmoplantar keratosis; autosomal recessive nonsyndromic deafness 91; familial encephalopathy with neuroserpin inclusion bodies; and thrombophilia (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB11 (serpin family B member 11); and SERPINB3 (serpin family B member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See srp-7 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (8179213..8183442)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GTP-binding protein Rheb Neighboring gene Histone H2A/H2B/H3 domain-containing protein Neighboring gene Serpin domain-containing protein Neighboring gene Methyltransferase FkbM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Luke CJ, et al. Front Biosci, 2006 Jan 1. PMID 16146754
    2. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak SC, et al. J Biol Chem, 2004 Apr 9. PMID 14739286
    3. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article
    4. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article
    5. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serpin domain-containing protein
    NP_001023823.1
    • Confirmed by transcript evidence
    NP_001023824.1
    • Confirmed by transcript evidence
    NP_001122924.1
    • Confirmed by transcript evidence
    NP_001379840.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8179213..8183442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129452.4 → NP_001122924.1  Serpin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9Z1L1
      Conserved Domains (1) summary
      cd19581
      Location:14 → 372
      serpinL_nematode; serpin family L, serpin family proteins from nematodes

    2. NM_001028652.8 → NP_001023823.1  Serpin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023823.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6QUQ6
      Conserved Domains (1) summary
      cd19581
      Location:7 → 365
      serpinL_nematode; serpin family L, serpin family proteins from nematodes

    3. NM_001392557.1 → NP_001379840.1  Serpin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBT3
      Conserved Domains (1) summary
      cd19581
      Location:7 → 365
      serpinL_nematode; serpin family L, serpin family proteins from nematodes

    4. NM_001028653.5 → NP_001023824.1  Serpin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023824.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6QUQ5
      Conserved Domains (1) summary
      cd19581
      Location:7 → 363
      serpinL_nematode; serpin family L, serpin family proteins from nematodes
    Nucleotide Protein
    Heading Accession and Version

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