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    hum-2 Dilute domain-containing protein;Myosin motor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179321, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hum-2
    Official Full Name
    Dilute domain-containing protein;Myosin motor domain-containing protein
    Primary source
    WormBase:WBGene00002036
    Locus tag
    CELE_F36D4.3
    See related
    AllianceGenome:WB:WBGene00002036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and vesicle. Is expressed in DB1. Used to study Griscelli syndrome type 1. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1; microvillus inclusion disease; and progressive familial intrahepatic cholestasis. Orthologous to human MYO5A (myosin VA); MYO5B (myosin VB); and MYO5C (myosin VC). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hum-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (9386175..9400063)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Trafficking protein particle complex subunit Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maternal UNC-45 is involved in cytokinesis and colocalizes with non-muscle myosin in the early Caenorhabditis elegans embryo. Kachur T, et al. J Cell Sci, 2004 Oct 15. PMID 15454571
    2. A family of unconventional myosins from the nematode Caenorhabditis elegans. Baker JP, et al. J Mol Biol, 1997 Oct 3. PMID 9325109
    3. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article
    4. EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans. Parry JM, et al. Curr Biol, 2009 Nov 3. PMID 19879147, Free PMC Article
    5. Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma. Trimmer KA, et al. Cell Rep, 2023 Jun 27. PMID 37227820, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dilute domain-containing protein;Myosin motor domain-containing protein
    NP_001317741.1
    • Confirmed by transcript evidence
    NP_001317742.1
    • Confirmed by transcript evidence
    NP_001317812.1
    • Confirmed by transcript evidence
    NP_001317813.1
    • Confirmed by transcript evidence
    NP_001317814.1
    • Confirmed by transcript evidence
    NP_001317815.1
    • Confirmed by transcript evidence
    NP_001317816.1
    • Confirmed by transcript evidence
    NP_001379851.1
    • Confirmed by transcript evidence
    NP_001379852.1
    • Confirmed by transcript evidence
    NP_741590.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9386175..9400063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330875.4 → NP_001317742.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JY81, Q17383, Q95ZU2
      Conserved Domains (4) summary
      smart00015
      Location:826 → 847
      IQ; Calmodulin-binding motif
      cd15470
      Location:1429 → 1803
      Myo5_CBD; Cargo binding domain of myosin 5
      cd01380
      Location:93 → 764
      MYSc_Myo5; class V myosin, motor domain
      pfam15921
      Location:864 → 1473
      CCDC158; Coiled-coil domain-containing protein 158

    2. NM_001330876.3 → NP_001317741.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17383, Q95ZU1, Q95ZU2
      Conserved Domains (4) summary
      smart00015
      Location:826 → 847
      IQ; Calmodulin-binding motif
      cd15470
      Location:1427 → 1801
      Myo5_CBD; Cargo binding domain of myosin 5
      cd01380
      Location:93 → 764
      MYSc_Myo5; class V myosin, motor domain
      pfam15921
      Location:864 → 1471
      CCDC158; Coiled-coil domain-containing protein 158

    3. NM_001392575.1 → NP_001379851.1  Dilute domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7K3
      Conserved Domains (1) summary
      cd15470
      Location:58 → 432
      Myo5_CBD; Cargo binding domain of myosin 5

    4. NM_001330877.3 → NP_001317812.1  Dilute domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H541
      Conserved Domains (2) summary
      cd15470
      Location:451 → 825
      Myo5_CBD; Cargo binding domain of myosin 5
      TIGR02168
      Location:3 → 291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. NM_001330878.3 → NP_001317813.1  Dilute domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A163UTE6
      Conserved Domains (2) summary
      cd15470
      Location:449 → 823
      Myo5_CBD; Cargo binding domain of myosin 5
      TIGR02168
      Location:3 → 289
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. NM_001330879.3 → NP_001317814.1  Dilute domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H5A5
      Conserved Domains (1) summary
      cd15470
      Location:412 → 786
      Myo5_CBD; Cargo binding domain of myosin 5

    7. NM_001330880.3 → NP_001317815.1  Dilute domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H5E2
      Conserved Domains (2) summary
      cd15470
      Location:410 → 784
      Myo5_CBD; Cargo binding domain of myosin 5
      TIGR02168
      Location:7 → 236
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. NM_001330881.3 → NP_001317816.1  Dilute domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H5H9
      Conserved Domains (2) summary
      pfam05483
      Location:140 → 303
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd15470
      Location:396 → 770
      Myo5_CBD; Cargo binding domain of myosin 5

    9. NM_171505.7 → NP_741590.1  Dilute domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYQ0
      Conserved Domains (1) summary
      cd15470
      Location:134 → 508
      Myo5_CBD; Cargo binding domain of myosin 5

    10. NM_001392576.1 → NP_001379852.1  Dilute domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7K2
      Conserved Domains (1) summary
      cl03379
      Location:47 → 242
      Myo5-like_CBD; Cargo binding domain of myosin 5 and similar proteins
    Nucleotide Protein
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