saeg-1 Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: saeg-1
Official Full Name: Suppressor of activated egl-4 protein 1
Primary source: WormBase:WBGene00010012
Locus tag: CELE_F53H10.2
See related: AllianceGenome:WB:WBGene00010012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein); TRERF1 (transcriptional regulating factor 1); and ZNF541 (zinc finger protein 541). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See saeg-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 15

Sequence:: Chromosome: V; NC_003283.11 (10852518..10865699, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53H10.2 (e-PCR)
- UniSTS:311759

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Suppressor of activated egl-4 protein 1

NP_001122952.1

Confirmed by transcript evidence

NP_001122953.1

Confirmed by transcript evidence

NP_001294697.1

Confirmed by transcript evidence

NP_505769.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10852518..10865699 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307768.4 → NP_001294697.1 Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

N1NTF3

Conserved Domains (3) summary

smart00717
Location:322 → 365

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00096
Location:493 → 515

zf-C2H2; Zinc finger, C2H2 type

cl21498
Location:322 → 365

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_073368.8 → NP_505769.2 Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20733

Conserved Domains (3) summary

smart00717
Location:565 → 608

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00096
Location:736 → 758

zf-C2H2; Zinc finger, C2H2 type

cl21498
Location:565 → 608

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001129480.4 → NP_001122952.1 Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A8WHS4

Conserved Domains (3) summary

smart00717
Location:341 → 384

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00096
Location:512 → 534

zf-C2H2; Zinc finger, C2H2 type

cl21498
Location:341 → 384

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001129481.4 → NP_001122953.1 Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A8WHS5

Conserved Domains (3) summary

smart00717
Location:245 → 288

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00096
Location:416 → 438

zf-C2H2; Zinc finger, C2H2 type

cl21498
Location:245 → 288

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...