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    pus-1 Pseudouridine synthase I TruA alpha/beta domain-containing protein;tRNA pseudouridine synthase [ Caenorhabditis elegans ]

    Gene ID: 180123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pus-1
    Official Full Name
    Pseudouridine synthase I TruA alpha/beta domain-containing protein;tRNA pseudouridine synthase
    Primary source
    WormBase:WBGene00004248
    Locus tag
    CELE_W06H3.2
    See related
    AllianceGenome:WB:WBGene00004248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pus-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (16792759..16794952, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase dkf-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MICOS complex subunit MIC60-2 Neighboring gene CTP synthase Neighboring gene Cullin-associated NEDD8-dissociated protein 1 Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide modifications in messenger RNA and their role in development and disease. Dezi V, et al. Biochem Soc Trans, 2016 Oct 15. PMID 27911721
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pseudouridine synthase I TruA alpha/beta domain-containing protein;tRNA pseudouridine synthase
    NP_001123028.1
    • Confirmed by transcript evidence
    NP_507242.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16792759..16794952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074841.8 → NP_507242.1  Pseudouridine synthase I TruA alpha/beta domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXN0
      Conserved Domains (1) summary
      cd02568
      Location:37 → 296
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like

    2. NM_001129556.3 → NP_001123028.1  tRNA pseudouridine synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123028.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1V8I7
      Conserved Domains (1) summary
      cl00130
      Location:3 → 18
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
    Nucleotide Protein
    Heading Accession and Version

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