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    unc-80 Protein unc-80 [ Caenorhabditis elegans ]

    Gene ID: 180374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-80
    Official Full Name
    Protein unc-80
    Primary source
    WormBase:WBGene00006812
    Locus tag
    CELE_F25C8.3
    See related
    AllianceGenome:WB:WBGene00006812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Is expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-80 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    37
    Sequence:
    Chromosome: V; NC_003283.11 (20879601..20898948)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MATH domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Amine oxidase domain-containing protein Neighboring gene 4-coumarate--CoA ligase 1-like Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Food deprivation and nicotine correct akinesia and freezing in Na(+) -leak current channel (NALCN)-deficient strains of Caenorhabditis elegans. Bonnett K, et al. Genes Brain Behav, 2014 Sep. PMID 24995777
    2. The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior. Zhou C, et al. G3 (Bethesda), 2020 Jan 7. PMID 31690562, Free PMC Article
    3. Structures of spontaneous deletions in Caenorhabditis elegans. Pulak RA, et al. Mol Cell Biol, 1988 Sep. PMID 3221864, Free PMC Article
    4. The effect of two genes on anesthetic response in the nematode Caenorhabditis elegans. Morgan PG, et al. Anesthesiology, 1988 Aug. PMID 2900611
    5. Genetic analysis of crawling and swimming locomotory patterns in C. elegans. Pierce-Shimomura JT, et al. Proc Natl Acad Sci U S A, 2008 Dec 30. PMID 19074276, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UNC-80 regulates C. elegans reversal behavior through command interneurons.
      Title: The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior.
    2. at least in part by transmitting depolarization signals to synapses in C. elegans neurons.
      Title: A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein unc-80
    NP_001023839.2
    • Confirmed by transcript evidence
    NP_001023840.2
    • Confirmed by transcript evidence
    NP_001129895.2
    • Confirmed by transcript evidence
    NP_001256961.1
    • Confirmed by transcript evidence
    NP_001256962.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20879601..20898948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028669.4 → NP_001023840.2  Protein unc-80 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023840.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XV66
      Conserved Domains (1) summary
      pfam15778
      Location:42 → 229
      UNC80; Cation channel complex component UNC80

    2. NM_001028668.4 → NP_001023839.2  Protein unc-80 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023839.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XV66
      Conserved Domains (2) summary
      TIGR03825
      Location:1845 → 2013
      FliH_bacil; flagellar assembly protein FliH
      pfam15778
      Location:42 → 229
      UNC80; Cation channel complex component UNC80

    3. NM_001270033.2 → NP_001256962.1  Protein unc-80 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256962.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XV66
      Conserved Domains (1) summary
      pfam15778
      Location:42 → 229
      UNC80; Cation channel complex component UNC80

    4. NM_001270032.3 → NP_001256961.1  Protein unc-80 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5U8P2, C1P651, H9G315, Q7JKT8, Q9XV66
      Conserved Domains (2) summary
      pfam15778
      Location:42 → 229
      UNC80; Cation channel complex component UNC80
      pfam19424
      Location:770 → 3065
      UNC80; Protein UNC80

    5. NM_001136423.4 → NP_001129895.2  Protein unc-80 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129895.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XV66
      Conserved Domains (1) summary
      pfam15778
      Location:24 → 211
      UNC80; Cation channel complex component UNC80
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XV66.4

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