gbb-1 G-protein coupled receptors family 3 profile domain-containing protein;Gamma-aminobutyric acid type B receptor subunit 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gbb-1
Official Full Name: G-protein coupled receptors family 3 profile domain-containing protein;Gamma-aminobutyric acid type B receptor subunit 1
Primary source: WormBase:WBGene00021528
Locus tag: CELE_Y41G9A.4
See related: AllianceGenome:WB:WBGene00021528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables G protein-coupled GABA receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gbb-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 21

Sequence:: Chromosome: X; NC_003284.9 (2957935..2968192)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GBB-1 regulates lifespan through G protein-PLCbeta signalling, which transmits longevity signals to the transcription factor DAF-16/FOXO, a key regulator of lifespan.
Title: Metabotropic GABA signalling modulates longevity in C. elegans.
The GABA-1/2 receptor contributes to acute body relaxation, evoked by photoactivation of GABAergic motor neurons, and to effects of GABA on locomotion behavior.
Title: Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons.

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Pathways from PubChem

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General gene information

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Markers

Y41G9A.d (e-PCR)
- UniSTS:322862

Y41G9A.c (e-PCR)
- UniSTS:323662

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled GABA receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled GABA receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled GABA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled GABA receptor complex	TAS Traceable Author Statement more info	PubMed
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptors family 3 profile domain-containing protein;Gamma-aminobutyric acid type B receptor subunit 1

NP_001256997.2

Confirmed by transcript evidence

NP_001300385.1

Confirmed by transcript evidence

NP_001300386.1

Confirmed by transcript evidence

NP_741740.3

Confirmed by transcript evidence

NP_741741.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2957935..2968192

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001270068.6 → NP_001256997.2 Gamma-aminobutyric acid type B receptor subunit 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0Q3

Conserved Domains (4) summary

cd06366
Location:25 → 414

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:460 → 721

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:44 → 399

ANF_receptor; Receptor family ligand binding region

pfam15898
Location:749 → 804

PRKG1_interact; cGMP-dependent protein kinase interacting domain
NM_171645.7 → NP_741740.3 Gamma-aminobutyric acid type B receptor subunit 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AVQ1, B3VBI8, B7CED7, H2L0Q3, Q9N502

Conserved Domains (3) summary

cd06366
Location:25 → 414

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam15898
Location:793 → 848

PRKG1_interact; cGMP-dependent protein kinase interacting domain

cd15291
Location:447 → 770

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
NM_001313456.4 → NP_001300385.1 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATD8

Conserved Domains (3) summary

cd15291
Location:447 → 737

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam15898
Location:760 → 815

PRKG1_interact; cGMP-dependent protein kinase interacting domain

cd06366
Location:25 → 426

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
NM_171646.6 → NP_741741.2 Gamma-aminobutyric acid type B receptor subunit 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0Q3

Conserved Domains (3) summary

cd06366
Location:25 → 414

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:460 → 509

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:44 → 399

ANF_receptor; Receptor family ligand binding region
NM_001313457.4 → NP_001300386.1 Gamma-aminobutyric acid type B receptor subunit 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0Q3

Conserved Domains (2) summary

pfam00003
Location:4 → 85

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam15898
Location:113 → 168

PRKG1_interact; cGMP-dependent protein kinase interacting domain