ztf-16 Zinc finger protein ztf-16 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ztf-16
Official Full Name: Zinc finger protein ztf-16
Primary source: WormBase:WBGene00019960
Locus tag: CELE_R08E3.4
See related: AllianceGenome:WB:WBGene00019960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gonad development and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including accessory cell; gonad; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; common variable immunodeficiency 13; and primary immunodeficiency disease. Orthologous to several human genes including IKZF1 (IKAROS family zinc finger 1); IKZF2 (IKAROS family zinc finger 2); and IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ztf-16 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (4805998..4811540, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ztf-16 functions within glia to regulate ver-1 expression.
Title: Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R08E3.4 (e-PCR)
- UniSTS:322273

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zinc finger protein ztf-16

NP_001024850.1

Confirmed by transcript evidence

NP_001024851.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4805998..4811540 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029680.6 → NP_001024851.1 Zinc finger protein ztf-16 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024851.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L008, Q5WRS1

Conserved Domains (1) summary

sd00017
Location:105 → 125

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001029679.5 → NP_001024850.1 Zinc finger protein ztf-16 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024850.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5WRS1

Conserved Domains (1) summary

sd00017
Location:105 → 125

ZF_C2H2; C2H2 Zn finger [structural motif]