him-4 EGF-like domain-containing protein;Ig-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: him-4
Official Full Name: EGF-like domain-containing protein;Ig-like domain-containing protein
Primary source: WormBase:WBGene00001863
Locus tag: CELE_F15G9.4
See related: AllianceGenome:WB:WBGene00001863
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: An extracellular matrix structural constituent. Involved in basement membrane disassembly. Located in basement membrane. Is expressed in body wall musculature; germ cell; germ line; gonad; and pharynx. Human ortholog(s) of this gene implicated in age related macular degeneration 1. Orthologous to several human genes including HMCN1 (hemicentin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See him-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 62

Sequence:: Chromosome: X; NC_003284.9 (9717565..9753764)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage.
Title: Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage.
HIM-4 is an extracellular factor that regulates ANI-1 for germ cell membrane stabilization and contractile ring formation in Caenorhabditis elegans germline cells.
Title: An extracellular matrix protein promotes anillin-dependent processes in the Caenorhabditis elegans germline.
study found that the extracellular matrix component hemicentin (HIM-4), found between Basement membrane (BM), forms punctate accumulations under the anchor cell and controls BM linkage to promote rapid invasion
Title: B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes.
A hemicentin fragment containing the von Willebrand A domain can target to multiple assembly sites when expressed under the control of either endogenous hemicentin regulatory sequences or the muscle-specific unc-54 promoter.
Title: Hemicentin assembly in the extracellular matrix is mediated by distinct structural modules.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F15G9.4 (e-PCR)
- UniSTS:309785

F15G9.5 (e-PCR)
- UniSTS:318111

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in basement membrane disassembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in basement membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: EGF-like domain-containing protein;Ig-like domain-containing protein

NP_001024582.1

Confirmed by transcript evidence

NP_001123132.1

Confirmed by transcript evidence

NP_001359724.1

Confirmed by transcript evidence

NP_001360633.1

Confirmed by transcript evidence

NP_001360634.1

Confirmed by transcript evidence

NP_509635.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9717565..9753764

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029411.3 → NP_001024582.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024582.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EG33

Conserved Domains (9) summary

smart00408
Location:2492 → 2556

IGc2; Immunoglobulin C-2 Type

smart00179
Location:5034 → 5076

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:527 → 605

IG; Immunoglobulin

smart00410
Location:4418 → 4496

IG_like; Immunoglobulin like

cd00054
Location:4996 → 5027

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00096
Location:1109 → 1172

Ig; Immunoglobulin domain

pfam07679
Location:3300 → 3386

I-set; Immunoglobulin I-set domain

pfam13927
Location:4045 → 4119

Ig_3; Immunoglobulin domain

cl11960
Location:899 → 974

Ig; Immunoglobulin domain
NM_077234.7 → NP_509635.2 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509635.2

Status: REVIEWED

UniProtKB/TrEMBL

G5ED27

Conserved Domains (9) summary

smart00408
Location:2492 → 2556

IGc2; Immunoglobulin C-2 Type

smart00179
Location:5011 → 5053

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:4418 → 4496

IG; Immunoglobulin

smart00410
Location:527 → 605

IG_like; Immunoglobulin like

cd00054
Location:4973 → 5004

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00096
Location:1109 → 1172

Ig; Immunoglobulin domain

pfam07679
Location:3300 → 3386

I-set; Immunoglobulin I-set domain

pfam13927
Location:4045 → 4119

Ig_3; Immunoglobulin domain

cl11960
Location:899 → 974

Ig; Immunoglobulin domain
NM_001373449.3 → NP_001359724.1 Ig-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EDG4

Conserved Domains (6) summary

smart00408
Location:2492 → 2556

IGc2; Immunoglobulin C-2 Type

smart00409
Location:442 → 515

IG; Immunoglobulin

smart00410
Location:2951 → 3031

IG_like; Immunoglobulin like

cd00096
Location:1109 → 1172

Ig; Immunoglobulin domain

pfam07679
Location:3300 → 3386

I-set; Immunoglobulin I-set domain

cl11960
Location:899 → 974

Ig; Immunoglobulin domain
NM_001373450.2 → NP_001360633.1 Ig-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0ILL2

Conserved Domains (9) summary

smart00408
Location:2394 → 2458

IGc2; Immunoglobulin C-2 Type

smart00179
Location:4936 → 4978

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:344 → 417

IG; Immunoglobulin

smart00410
Location:4320 → 4398

IG_like; Immunoglobulin like

cd00054
Location:4898 → 4929

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00096
Location:1011 → 1074

Ig; Immunoglobulin domain

pfam07679
Location:3202 → 3288

I-set; Immunoglobulin I-set domain

pfam13927
Location:3947 → 4021

Ig_3; Immunoglobulin domain

cl11960
Location:801 → 876

Ig; Immunoglobulin domain
NM_001373451.2 → NP_001360634.1 Ig-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IK01

Conserved Domains (9) summary

smart00408
Location:2394 → 2458

IGc2; Immunoglobulin C-2 Type

smart00179
Location:4913 → 4955

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:429 → 507

IG; Immunoglobulin

smart00410
Location:4320 → 4398

IG_like; Immunoglobulin like

cd00054
Location:4875 → 4906

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00096
Location:1011 → 1074

Ig; Immunoglobulin domain

pfam07679
Location:3202 → 3288

I-set; Immunoglobulin I-set domain

pfam13927
Location:3947 → 4021

Ig_3; Immunoglobulin domain

cl11960
Location:801 → 876

Ig; Immunoglobulin domain
NM_001129660.3 → NP_001123132.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001123132.1

Status: REVIEWED

UniProtKB/TrEMBL

A4UVK0

Conserved Domains (2) summary

smart00179
Location:48 → 90

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:10 → 41

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...