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    Dred Dctn1-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dredprovided by FlyBase
    Official Full Name
    Dctn1-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036882
    Locus tag
    Dmel_CG9279
    See related
    AllianceGenome:FB:FBgn0036882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9279; Dmel\CG9279; P150B
    Summary
    Predicted to be involved in establishment of mitotic spindle orientation; intracellular protein transport; and nuclear migration. Predicted to be part of dynactin complex. Predicted to be active in axon; kinetochore; and spindle pole. Is expressed in several structures, including embryonic/larval midgut primordium; fat body/gonad primordium; foregut primordium; plasmatocyte primordium; and posterior endoderm. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dred in Genome Data Viewer
    Location:
    76B6-76B6; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19538425..19544205, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19531525..19537272, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 76Bc Neighboring gene Cuticular protein 76Bd Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43885 Neighboring gene uncharacterized protein Neighboring gene Listerin E3 ubiquitin protein ligase 1 Neighboring gene Reduction in Cnn dots 7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dctn1-related
    Names
    CG9279-PB
    CG9279-PC
    Dred-PB
    Dred-PC
    Dynactin1 p150 B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19538425..19544205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168801.2 → NP_730426.1  Dctn1-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQV2, Q86NU4
      Related
      FBpp0074744
      Conserved Domains (5) summary
      COG1196
      Location:422 → 1276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5244
      Location:7 → 642
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:10 → 74
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:702 → 965
      Dynactin; Dynein associated protein
      cl23943
      Location:422 → 490
      PCRF; PCRF domain

    2. NM_140867.3 → NP_649124.1  Dctn1-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQV2, Q86NU4
      Related
      FBpp0304997
      Conserved Domains (5) summary
      COG1196
      Location:422 → 1276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5244
      Location:7 → 642
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:10 → 74
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:702 → 965
      Dynactin; Dynein associated protein
      cl23943
      Location:422 → 490
      PCRF; PCRF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQV2 Q7JQV2
    Q86NU4 Q86NU4

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