M04G7.2 Protein-tyrosine phosphatase;Tyrosine-protein phosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: M04G7.2
Official Full Name: Protein-tyrosine phosphatase;Tyrosine-protein phosphatase
Primary source: WormBase:WBGene00019773
Locus tag: CELE_M04G7.2
See related: AllianceGenome:WB:WBGene00019773
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in axon guidance and signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See M04G7.2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (458017..461029, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M04G7.2 (e-PCR)
- UniSTS:311986

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Protein-tyrosine phosphatase;Tyrosine-protein phosphatase

NP_001294337.1

Partially confirmed by transcript evidence

NP_499934.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

458017..461029 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067533.5 → NP_499934.1 Protein-tyrosine phosphatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499934.1

Status: REVIEWED

UniProtKB/TrEMBL

O44180

Conserved Domains (2) summary

smart00194
Location:266 → 520

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:292 → 520

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001307408.3 → NP_001294337.1 Tyrosine-protein phosphatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294337.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBF5

Conserved Domains (2) summary

smart00194
Location:264 → 518

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:290 → 518

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...