Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Maffprovided by MGI
Official Full Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)provided by MGI
Primary source: MGI:MGI:96910
See related: Ensembl:ENSMUSG00000042622 AllianceGenome:MGI:96910
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within in utero embryonic development; regulation of epidermal cell differentiation; and skeletal muscle cell differentiation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human MAFF (MAF bZIP transcription factor F). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in small intestine adult (RPKM 12.2), duodenum adult (RPKM 12.0) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79230813..79243278)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79346621..79359078)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis.
Title: HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis.
Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism.
Title: Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism.
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
Title: Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
mafG::mafK::mafF triple-mutant fibroblasts that completely lack small Mafs are highly susceptible to oxidative stress. (mafF)
Title: Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Maff (e-PCR), detects polymorphism
- UniSTS:274180

Maff (e-PCR), detects polymorphism
- UniSTS:257102

Maff (e-PCR), detects polymorphism
- UniSTS:257103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of epidermal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor MafF

Names: V-maf musculoaponeurotic fibrosarcoma oncogene homolog F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304830.2 → NP_001291759.1 transcription factor MafF

See identical proteins and their annotated locations for NP_001291759.1

Status: VALIDATED

Source sequence(s)

AC165278

Consensus CDS

CCDS27638.1

UniProtKB/Swiss-Prot

O54791

UniProtKB/TrEMBL

Q3U0G5, Q3UKW6

Related

ENSMUSP00000154850.2, ENSMUST00000229130.2

Conserved Domains (1) summary

cd14717
Location:47 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
NM_001304831.2 → NP_001291760.2 transcription factor MafF

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/Swiss-Prot

O54791

UniProtKB/TrEMBL

Q3U0G5

Related

ENSMUSP00000131628.2, ENSMUST00000163691.3
NM_001304832.3 → NP_001291761.2 transcription factor MafF

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/Swiss-Prot

O54791

UniProtKB/TrEMBL

Q3U0G5
NM_010755.5 → NP_034885.1 transcription factor MafF

See identical proteins and their annotated locations for NP_034885.1

Status: VALIDATED

Source sequence(s)

AC165278

Consensus CDS

CCDS27638.1

UniProtKB/Swiss-Prot

O54791

UniProtKB/TrEMBL

Q3U0G5, Q3UKW6

Related

ENSMUSP00000094076.4, ENSMUST00000096350.11

Conserved Domains (1) summary

cd14717
Location:47 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79230813..79243278

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159212.1 → XP_036015105.1 transcription factor MafF isoform X1

Conserved Domains (1) summary

cd14717
Location:158 → 226

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_036159213.1 → XP_036015106.1 transcription factor MafF isoform X2

UniProtKB/Swiss-Prot

O54791

UniProtKB/TrEMBL

Q3U0G5, Q3UKW6

Conserved Domains (1) summary

cd14717
Location:47 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
XM_006520550.5 → XP_006520613.1 transcription factor MafF isoform X2

See identical proteins and their annotated locations for XP_006520613.1

UniProtKB/Swiss-Prot

O54791

UniProtKB/TrEMBL

Q3U0G5, Q3UKW6

Conserved Domains (1) summary

cd14717
Location:47 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain