BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: BANPprovided by HGNC
Official Full Name: BTG3 associated nuclear proteinprovided by HGNC
Primary source: HGNC:HGNC:13450
See related: Ensembl:ENSG00000172530 MIM:611564; AllianceGenome:HGNC:13450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BEND1; SMAR1; SMARBP1
Summary: This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression: Ubiquitous expression in testis (RPKM 1.3), spleen (RPKM 1.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q24.2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (87949238..88077318)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (94021837..94148506)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (87982844..88110924)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of DNA recognition by BEN domain proteins reveals a role for oligomerization in unmethylated DNA selection by BANP.
Title: Structural basis of DNA recognition by BEN domain proteins reveals a role for oligomerization in unmethylated DNA selection by BANP.
SMAR1 suppresses the cancer stem cell population via hTERT repression in colorectal cancer cells.
Title: SMAR1 suppresses the cancer stem cell population via hTERT repression in colorectal cancer cells.
BANP Participates in the Chronic Intermittent Hypoxia-Induced Senescence of Vascular Endothelial Cells by Promoting P53 Phosphorylation and Nuclear Retention.
Title: BANP Participates in the Chronic Intermittent Hypoxia-Induced Senescence of Vascular Endothelial Cells by Promoting P53 Phosphorylation and Nuclear Retention.
Nuclear Matrix-associated Protein SMAR1 Attenuated Acute Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 + T Cells.
Title: Nuclear Matrix-associated Protein SMAR1 Attenuated Acute Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 + T Cells.
ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma.
Title: ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma.
Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
Title: Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin.
Title: SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin.
BANP opens chromatin and activates CpG-island-regulated genes.
Title: BANP opens chromatin and activates CpG-island-regulated genes.
our observations establish that increased expression of SMAR1 in cancers can positively regulate MHC I surface expression thereby leading to higher chances of tumor regression and elimination of cancer cells.
Title: SMAR1 favors immunosurveillance of cancer cells by modulating calnexin and MHC I expression.
Cdc20 functions as an important negative regulator of SMAR1 in higher grades of cancer
Title: Cdc20 directs proteasome-mediated degradation of the tumor suppressor SMAR1 in higher grades of cancer through the anaphase promoting complex.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci at chromosomes 13, 19 and 20 influence age at natural menopause. EBI GWAS Catalog EBI GWAS CatalogPubMed
New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	SMAR1 recruits HDAC1-Sin3 corepressor complex to remodel chromatin structure at HIV-1 LTR. Overexpression of SMAR1 leads to reduction in LTR-mediated transcription in a Tat dependent and independent manner, resulting in a decreased virion production	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein BANP

Names: BEN domain-containing protein 1; scaffold/matrix-associated region-1-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029918.1 RefSeqGene

Range

5003..130885

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001173539.2 → NP_001167010.1 protein BANP isoform c

See identical proteins and their annotated locations for NP_001167010.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses one alternate in-frame splices site, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (c) differs at two internal regions, compared to isoform g. Variants 3 and 9-11 all encode the same isoform (c).

Source sequence(s)

AK001039, AK125232, AK293472, AL157429

Consensus CDS

CCDS92204.1

UniProtKB/TrEMBL

B3KM38, B4DE54

Related

ENSP00000515015.1, ENST00000700483.1

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001173540.2 → NP_001167011.1 protein BANP isoform d

See identical proteins and their annotated locations for NP_001167011.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses three alternate in-frame splices sites, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (d) differs at four internal regions, compared to isoform g.

Source sequence(s)

AK001039, AK125232, AK297945, AL157429

Consensus CDS

CCDS54055.1

UniProtKB/TrEMBL

B3KM38

Related

ENSP00000487304.1, ENST00000626016.2

Conserved Domains (1) summary

smart01025
Location:224 → 297

BEN; The BEN domain is found in diverse animal proteins
NM_001173541.2 → NP_001167012.1 protein BANP isoform e

See identical proteins and their annotated locations for NP_001167012.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR, uses one alternate in-frame splices site, and lacks two alternate in-frame exons in the coding region, compared to variant 7. The resulting isoform (e) differs at three internal regions, compared to isoform g. Variants 5 and 12-14 all encode the same isoform (e).

Source sequence(s)

AK001039, AK297945, AK315089, AL157429

Consensus CDS

CCDS54053.1

UniProtKB/TrEMBL

B3KM38

Related

ENSP00000432508.1, ENST00000479780.6

Conserved Domains (1) summary

smart01025
Location:218 → 291

BEN; The BEN domain is found in diverse animal proteins
NM_001173542.1 → NP_001167013.1 protein BANP isoform f

See identical proteins and their annotated locations for NP_001167013.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices site, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (f) differs at three internal regions, compared to isoform g. Variants 6 and 15-17 all encode the same isoform (f).

Source sequence(s)

AK293472, AK297945, AK315535, AL157429

Consensus CDS

CCDS54052.1

UniProtKB/TrEMBL

A0A0S2Z5M2, B3KM38

Related

ENSP00000444352.1, ENST00000538234.5

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001173543.1 → NP_001167014.1 protein BANP isoform g

See identical proteins and their annotated locations for NP_001167014.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) represents the longest transcript and encodes the longest isoform (g).

Source sequence(s)

AC127455, AK001039, AK094158, AK125232, AL157429

Consensus CDS

CCDS54054.1

UniProtKB/Swiss-Prot

A8MU25, A8MX25, B2RCF7, B4DNJ9, F5GZM0, Q8N9N5, Q96GJ7, Q9NWY1

UniProtKB/TrEMBL

B3KM38

Related

ENSP00000376902.1, ENST00000393207.5

Conserved Domains (1) summary

smart01025
Location:249 → 322

BEN; The BEN domain is found in diverse animal proteins
NM_001384916.1 → NP_001371845.1 protein BANP isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variant 1, encodes isoform a.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS42215.1

UniProtKB/TrEMBL

A0A0S2Z5C2, B3KM38

Conserved Domains (1) summary

smart01025
Location:218 → 291

BEN; The BEN domain is found in diverse animal proteins
NM_001384918.1 → NP_001371847.1 protein BANP isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 3, 10, and 11, encodes isoform c.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS92204.1

UniProtKB/TrEMBL

B3KM38, B4DE54

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001384919.1 → NP_001371848.1 protein BANP isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 3, 9, and 11, encodes isoform c.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS92204.1

UniProtKB/TrEMBL

B3KM38, B4DE54

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001384920.1 → NP_001371849.1 protein BANP isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variants 3, 9, and 10, encodes isoform c.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS92204.1

UniProtKB/TrEMBL

B3KM38, B4DE54

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001384921.1 → NP_001371850.1 protein BANP isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 5, 13, and 14, encodes isoform e.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS54053.1

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:218 → 291

BEN; The BEN domain is found in diverse animal proteins
NM_001384922.1 → NP_001371851.1 protein BANP isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 5, 12, and 14, encodes isoform e.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS54053.1

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:218 → 291

BEN; The BEN domain is found in diverse animal proteins
NM_001384923.1 → NP_001371852.1 protein BANP isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 5, 12, and 13, encodes isoform e.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS54053.1

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:218 → 291

BEN; The BEN domain is found in diverse animal proteins
NM_001384925.1 → NP_001371854.1 protein BANP isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variants 6, 16, and 17, encodes isoform f.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS54052.1

UniProtKB/TrEMBL

A0A0S2Z5M2, B3KM38

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001384926.1 → NP_001371855.1 protein BANP isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (16), as well as variants 6, 15, and 17, encodes isoform f.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS54052.1

UniProtKB/TrEMBL

A0A0S2Z5M2, B3KM38

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001384927.1 → NP_001371856.1 protein BANP isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (17), as well as variants 6, 15, and 16, encodes isoform f.

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS54052.1

UniProtKB/TrEMBL

A0A0S2Z5M2, B3KM38

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001384928.1 → NP_001371857.1 protein BANP isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (18), as well as variant 19, encodes isoform h.

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:263 → 336

BEN; The BEN domain is found in diverse animal proteins
NM_001384929.1 → NP_001371858.1 protein BANP isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (19), as well as variant 18, encodes isoform h.

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:263 → 336

BEN; The BEN domain is found in diverse animal proteins
NM_001384931.1 → NP_001371860.1 protein BANP isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (20), as well as variant 21, encodes isoform i.

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:263 → 336

BEN; The BEN domain is found in diverse animal proteins
NM_001384935.1 → NP_001371864.1 protein BANP isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (21), as well as variant 20, encodes isoform i.

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:263 → 336

BEN; The BEN domain is found in diverse animal proteins
NM_001384936.1 → NP_001371865.1 protein BANP isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (22), as well as variant 23, encodes isoform j.

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:224 → 297

BEN; The BEN domain is found in diverse animal proteins
NM_001384937.1 → NP_001371866.1 protein BANP isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (23), as well as variant 22, encodes isoform j.

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:224 → 297

BEN; The BEN domain is found in diverse animal proteins
NM_001384938.1 → NP_001371867.1 protein BANP isoform k

Status: REVIEWED

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:224 → 297

BEN; The BEN domain is found in diverse animal proteins
NM_001384939.1 → NP_001371868.1 protein BANP isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (25), as well as variant 26, encodes isoform l.

Source sequence(s)

AC127455, AC134312

Conserved Domains (1) summary

smart01025
Location:154 → 227

BEN; The BEN domain is found in diverse animal proteins
NM_001384940.1 → NP_001371869.1 protein BANP isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (26), as well as variant 25, encodes isoform l.

Source sequence(s)

AC127455, AC134312

Conserved Domains (1) summary

smart01025
Location:154 → 227

BEN; The BEN domain is found in diverse animal proteins
NM_001384941.1 → NP_001371870.1 protein BANP isoform m

Status: REVIEWED

Description

Transcript Variant: This variant (27), as well as variant 28, encodes isoform m.

Source sequence(s)

AC127455, AC134312

Conserved Domains (1) summary

smart01025
Location:154 → 227

BEN; The BEN domain is found in diverse animal proteins
NM_001384942.1 → NP_001371871.1 protein BANP isoform m

Status: REVIEWED

Description

Transcript Variant: This variant (28), as well as variant 27, encodes isoform m.

Source sequence(s)

AC127455, AC134312

Conserved Domains (1) summary

smart01025
Location:154 → 227

BEN; The BEN domain is found in diverse animal proteins
NM_001384943.1 → NP_001371872.1 protein BANP isoform n

Status: REVIEWED

Source sequence(s)

AC127455, AC134312

Conserved Domains (1) summary

smart01025
Location:115 → 188

BEN; The BEN domain is found in diverse animal proteins
NM_001384944.1 → NP_001371873.1 protein BANP isoform o

Status: REVIEWED

Source sequence(s)

AC127455, AC134312

Conserved Domains (1) summary

smart01025
Location:115 → 188

BEN; The BEN domain is found in diverse animal proteins
NM_001386991.1 → NP_001373920.1 protein BANP isoform p

Status: REVIEWED

Source sequence(s)

AC127455, AC134312

Consensus CDS

CCDS92203.1

UniProtKB/TrEMBL

A0A804HKG3, B3KM38

Related

ENSP00000507916.1, ENST00000682872.1

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001386992.1 → NP_001373921.1 protein BANP isoform q

Status: REVIEWED

Source sequence(s)

AC127455, AC134312

UniProtKB/TrEMBL

B3KM38

Conserved Domains (1) summary

smart01025
Location:257 → 330

BEN; The BEN domain is found in diverse animal proteins
NM_001424170.1 → NP_001411099.1 protein BANP isoform c

Status: REVIEWED

Source sequence(s)

CP068262

UniProtKB/TrEMBL

B3KM38, B4DE54
NM_017869.4 → NP_060339.2 protein BANP isoform a

See identical proteins and their annotated locations for NP_060339.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices sites, and lacks two alternate in-frame exons in the coding region, compared to variant 7. The resulting isoform (a) differs at four internal regions, compared to isoform g. Variants 1 and 8 both encode the same isoform (a).

Source sequence(s)

AK000545, AK001039, BC009424, CN289917, DA632793, T49823

Consensus CDS

CCDS42215.1

UniProtKB/TrEMBL

A0A0S2Z5C2, B3KM38

Related

ENSP00000347125.4, ENST00000355022.8

Conserved Domains (1) summary

smart01025
Location:218 → 291

BEN; The BEN domain is found in diverse animal proteins
NM_079837.3 → NP_524576.2 protein BANP isoform b

See identical proteins and their annotated locations for NP_524576.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices sites, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (b) differs at three internal regions, compared to isoform g.

Source sequence(s)

AK001039, AK125232, CN289917

Consensus CDS

CCDS10966.2

UniProtKB/TrEMBL

B3KM38

Related

ENSP00000376903.2, ENST00000393208.6

Conserved Domains (1) summary

smart01025
Location:218 → 291

BEN; The BEN domain is found in diverse animal proteins