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    UBXN11 UBX domain protein 11 [ Homo sapiens (human) ]

    Gene ID: 91544, updated on 27-Nov-2024

    Summary

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    Official Symbol
    UBXN11provided by HGNC
    Official Full Name
    UBX domain protein 11provided by HGNC
    Primary source
    HGNC:HGNC:30600
    See related
    Ensembl:ENSG00000158062 MIM:609151; AllianceGenome:HGNC:30600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SOC; SOCI; COA-1; UBXD5; PP2243
    Summary
    This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 18.9), spleen (RPKM 17.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UBXN11 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26282282..26318355, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26119766..26155807, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26608773..26644846, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 Neighboring gene mitochondrial ribosomal protein S6 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:26602348-26603547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606098-26606985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606986-26607872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26610368-26610958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 487 Neighboring gene SH3 domain binding glutamate rich protein like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26616244-26617056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26617057-26617870 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:26629035-26630234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 494 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26644239-26644431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26645229-26646214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26648235-26648736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26655253-26655760 Neighboring gene crystallin beta-gamma domain containing 2 Neighboring gene CD52 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 476 Neighboring gene ribosomal protein L34 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26672818-26673571 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:26675860-26676706 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26677922-26678120 Neighboring gene Sharpr-MPRA regulatory region 4973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26688162-26688861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26690731-26691232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26691233-26691732 Neighboring gene zinc finger protein 683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. UBXN11 Predicts as a Poor Index for Colorectal Cancer and Contributes to the Tumorigenesis by Activating NF-κB Signaling. Chen X, et al. Dig Dis Sci, 2024 Jun. PMID 38622461
    2. Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes. Maccalli C, et al. Cancer Res, 2003 Oct 15. PMID 14583468, Free PMC Article
    3. Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation. Tateiwa K, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16202387
    4. Induction of both CD8+ and CD4+ T-cell-mediated responses in colorectal cancer patients by colon antigen-1. Maccalli C, et al. Clin Cancer Res, 2008 Nov 15. PMID 18974390
    5. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Katoh H, et al. Mol Cell Biol, 2002 May. PMID 11940653, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBXN11 Predicts as a Poor Index for Colorectal Cancer and Contributes to the Tumorigenesis by Activating NF-kappaB Signaling.
      Title: UBXN11 Predicts as a Poor Index for Colorectal Cancer and Contributes to the Tumorigenesis by Activating NF-κB Signaling.
    2. Both CD4+ and CD8+ T-cell responses against COA-1 can occur in colorectal cancer patients with metastatic disease
      Title: Induction of both CD8+ and CD4+ T-cell-mediated responses in colorectal cancer patients by colon antigen-1.
    3. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers
      Title: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.
    4. The rat homolog of UBXD5 promotes RhoA activation through G12/13 heterotrimeric G proteins
      Title: Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • DKFZp686F04228

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    UBX domain-containing protein 11
    Names
    UBX domain-containing protein 5
    colorectal tumor-associated antigen COA-1
    colorectal tumor-associated antigen-1
    socius

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028986.1 RefSeqGene

      Range
      16630..40984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077262.2 → NP_001070730.1  UBX domain-containing protein 11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL451139
      Consensus CDS
      CCDS41287.1
      UniProtKB/Swiss-Prot
      Q5T124
      Related
      ENSP00000324721.7, ENST00000314675.11
      Conserved Domains (2) summary
      pfam08059
      Location:115 → 185
      SEP; SEP domain
      cl00155
      Location:275 → 343
      UBQ; Ubiquitin-like proteins

    2. NM_001389556.1 → NP_001376485.1  UBX domain-containing protein 11 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL451139
      Consensus CDS
      CCDS41288.1
      UniProtKB/Swiss-Prot
      D3DPK6, Q5T117, Q5T120, Q5T124, Q5T125, Q5T126, Q5T129, Q5T131, Q5T133, Q63HM6, Q71RB3, Q8IY27, Q8N1L6, Q8N9M4, Q8NA18, Q8NFE3, Q8NFE4, Q8NFE6
      Related
      ENSP00000363339.1, ENST00000374222.6
      Conserved Domains (3) summary
      PRK13405
      Location:119 → 256
      bchH; magnesium chelatase subunit H; Provisional
      cd17077
      Location:395 → 464
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:235 → 306
      SEP; SEP domain

    3. NM_001389559.1 → NP_001376488.1  UBX domain-containing protein 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL451139
      Consensus CDS
      CCDS41286.1
      Related
      ENSP00000349601.4, ENST00000357089.8
      Conserved Domains (3) summary
      PRK13405
      Location:86 → 223
      bchH; magnesium chelatase subunit H; Provisional
      cd17077
      Location:362 → 431
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:202 → 273
      SEP; SEP domain

    4. NM_145345.3 → NP_663320.2  UBX domain-containing protein 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL451139
      Consensus CDS
      CCDS41286.1
      UniProtKB/Swiss-Prot
      Q5T124
      Related
      ENSP00000363334.2, ENST00000374217.7
      Conserved Domains (3) summary
      PRK13405
      Location:86 → 223
      bchH; magnesium chelatase subunit H; Provisional
      cd17077
      Location:362 → 431
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:202 → 273
      SEP; SEP domain

    5. NM_183008.3 → NP_892120.2  UBX domain-containing protein 11 isoform 2

      See identical proteins and their annotated locations for NP_892120.2

      Status: REVIEWED

      Source sequence(s)
      AL451139
      Consensus CDS
      CCDS41288.1
      UniProtKB/Swiss-Prot
      D3DPK6, Q5T117, Q5T120, Q5T124, Q5T125, Q5T126, Q5T129, Q5T131, Q5T133, Q63HM6, Q71RB3, Q8IY27, Q8N1L6, Q8N9M4, Q8NA18, Q8NFE3, Q8NFE4, Q8NFE6
      Related
      ENSP00000363338.3, ENST00000374221.7
      Conserved Domains (3) summary
      PRK13405
      Location:119 → 256
      bchH; magnesium chelatase subunit H; Provisional
      cd17077
      Location:395 → 464
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:235 → 306
      SEP; SEP domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      26282282..26318355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      26119766..26155807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T124.2 GenPept UniProtKB/Swiss-Prot:Q5T124

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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