Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myh7provided by MGI
Official Full Name: myosin, heavy polypeptide 7, cardiac muscle, betaprovided by MGI
Primary source: MGI:MGI:2155600
See related: Ensembl:ENSMUSG00000053093 AllianceGenome:MGI:2155600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B-MHC; Myhcb; MyHC-I; Myhc-b; betaMHC; beta-MHC; myHC-beta; myHC-slow; MYH-beta/slow
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and actin filament binding activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress and transition between fast and slow fiber. Located in Z disc and stress fiber. Part of myosin complex. Is expressed in several structures, including diaphragm; eye; heart; musculature; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward heart adult (RPKM 264.5) See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.01 cM

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55208141..55232083, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54970684..54994626, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model.
Title: Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model.
Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
Title: Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development.
Title: Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development.
We developed a new image-analysis pipeline to allow automated and unbiased quantification of gene expression at the single-cell level and determined the spatial and temporal regulation of heterogenous Myh7 expression in cardiomyocytes after pressure overload.
Title: High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.
These data demonstrate functional cooperation between Sox6 and Nfix in regulating MyHC-I expression during prenatal muscle development.[MyHC-1]
Title: Nfix Induces a Switch in Sox6 Transcriptional Activity to Regulate MyHC-I Expression in Fetal Muscle.
Male/female Myh7 mutant mice display sex dimorphic crossbridge kinetics accompanied by sex- and hypertrophic cardiomyopathy-dependent cardiac remodeling at the morphometric, histological, and cellular level.
Title: Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice.
The promoter regions of the SERCA-2A and beta-MHC genes, Atp2a2 and Myh7, respectively in murine hearts after one or eight weeks of pressure overload induced by transverse aortic constriction, were evaluated.
Title: Epigenetic switch at atp2a2 and myh7 gene promoters in pressure overload-induced heart failure.
Foxo1 has important roles in promoting diabetic cardiomyopathy and controls beta-MHC expression in the development of cardiac dysfunction.
Title: Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and β-myosin heavy chain gene expression.
Transgenic mouse alpha- and beta-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.
Title: Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.
Cooperative/allosteric effects on actomyosin crossbridge recruitment dynamics are increased by beta-MHC.
Title: Length-dependent effects on cardiac contractile dynamics are different in cardiac muscle containing α- or β-myosin heavy chain.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Not Applicable (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myh7 (e-PCR), detects polymorphism
- UniSTS:532517

Myh7 (e-PCR), detects polymorphism
- UniSTS:463417

Myhcb (e-PCR), detects polymorphism
- UniSTS:143962

Myh7 (e-PCR), detects polymorphism
- UniSTS:265580

RH140569 (e-PCR)
- UniSTS:222638

Myh7 (e-PCR), detects polymorphism
- UniSTS:530876

MARC_5445-5446:996690391:1 (e-PCR)
- UniSTS:269515

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in adult heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in adult heart development	IEA Inferred from Electronic Annotation more info
involved_in adult heart development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle filament sliding	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle filament sliding	IEA Inferred from Electronic Annotation more info
involved_in muscle filament sliding	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of slow-twitch skeletal muscle fiber contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of slow-twitch skeletal muscle fiber contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of the force of skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in striated muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transition between fast and slow fiber	IDA Inferred from Direct Assay more info	PubMed
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of muscle myosin complex	ISO Inferred from Sequence Orthology more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	ISO Inferred from Sequence Orthology more info
located_in myosin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISS Inferred from Sequence or Structural Similarity more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin-7

Names: myosin heavy chain 7; myosin heavy chain, cardiac muscle, fetal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361607.1 → NP_001348536.1 myosin-7

Status: VALIDATED

Source sequence(s)

CT025533

Consensus CDS

CCDS27106.1

UniProtKB/Swiss-Prot

Q3TGM2, Q3TZN2, Q91Z83

UniProtKB/TrEMBL

B2RXX9, B2RY26

Related

ENSMUSP00000126840.2, ENSMUST00000168485.8

Conserved Domains (3) summary

COG5022
Location:37 → 1432

COG5022; Myosin heavy chain [General function prediction only]

TIGR02168
Location:1173 → 1930

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01377
Location:99 → 766

MYSc_class_II; class II myosins, motor domain
NM_001425737.1 → NP_001412666.1 myosin-7

Status: VALIDATED

Source sequence(s)

CT025533

UniProtKB/Swiss-Prot

Q3TGM2, Q3TZN2, Q91Z83

UniProtKB/TrEMBL

B2RXX9, B2RY26
NM_080728.3 → NP_542766.1 myosin-7

See identical proteins and their annotated locations for NP_542766.1

Status: VALIDATED

Source sequence(s)

CT025533

Consensus CDS

CCDS27106.1

UniProtKB/Swiss-Prot

Q3TGM2, Q3TZN2, Q91Z83

UniProtKB/TrEMBL

B2RXX9, B2RY26

Related

ENSMUSP00000099867.4, ENSMUST00000102803.11

Conserved Domains (3) summary

COG5022
Location:37 → 1432

COG5022; Myosin heavy chain [General function prediction only]

TIGR02168
Location:1173 → 1930

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01377
Location:99 → 766

MYSc_class_II; class II myosins, motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

55208141..55232083 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158456.1 → XP_036014349.1 myosin-7 isoform X1

UniProtKB/Swiss-Prot

Q3TGM2, Q3TZN2, Q91Z83

UniProtKB/TrEMBL

B2RXX9, B2RY26

Conserved Domains (3) summary

COG5022
Location:37 → 1432

COG5022; Myosin heavy chain [General function prediction only]

TIGR02168
Location:1173 → 1930

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01377
Location:99 → 766

MYSc_class_II; class II myosins, motor domain
XM_017315841.3 → XP_017171330.1 myosin-7 isoform X1

UniProtKB/Swiss-Prot

Q3TGM2, Q3TZN2, Q91Z83

UniProtKB/TrEMBL

B2RXX9, B2RY26

Conserved Domains (3) summary

COG5022
Location:37 → 1432

COG5022; Myosin heavy chain [General function prediction only]

TIGR02168
Location:1173 → 1930

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01377
Location:99 → 766

MYSc_class_II; class II myosins, motor domain