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    MPO myeloperoxidase [ Homo sapiens (human) ]

    Gene ID: 4353, updated on 10-Dec-2024

    Summary

    Official Symbol
    MPOprovided by HGNC
    Official Full Name
    myeloperoxidaseprovided by HGNC
    Primary source
    HGNC:HGNC:7218
    See related
    Ensembl:ENSG00000005381 MIM:606989; AllianceGenome:HGNC:7218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
    Expression
    Restricted expression toward bone marrow (RPKM 1596.3) See more
    Orthologs
    NEW
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    Genomic context

    See MPO in Genome Data Viewer
    Location:
    17q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (58269855..58280935, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (59137736..59148814, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56347216..56358296, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12461 Neighboring gene uncharacterized LOC105371841 Neighboring gene uncharacterized LOC124904038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56326145-56326710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12462 Neighboring gene lactoperoxidase Neighboring gene enhancer region in introns 7-9 of MPO Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:56355955-56356644 Neighboring gene MPO proximal enhancer and promoter region Neighboring gene MPO upstream enhancer region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:56379736-56380356 Neighboring gene Sharpr-MPRA regulatory region 10051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56386896-56387595 Neighboring gene TSPO associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56389497-56390115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56402416-56402964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8764 Neighboring gene TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12466 Neighboring gene MIR142 host genes Neighboring gene microRNA 142

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Alzheimer disease type 1
    MedGen: C1863052 OMIM: 104300 GeneReviews: Alzheimer Disease Overview
    Compare labs
    Myeloperoxidase deficiency
    MedGen: C0398595 OMIM: 254600 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of myeloperoxidase (MPO) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates myeloperoxidase in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hypochlorous acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory burst involved in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to food IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to gold nanoparticle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to yeast IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009629.1 RefSeqGene

      Range
      5001..16080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_84

    mRNA and Protein(s)

    1. NM_000250.2NP_000241.1  myeloperoxidase precursor

      See identical proteins and their annotated locations for NP_000241.1

      Status: REVIEWED

      Source sequence(s)
      AC004687, M19507
      Consensus CDS
      CCDS11604.1
      UniProtKB/Swiss-Prot
      A1L4B8, P05164, Q14862, Q4PJH5, Q9UCL7
      Related
      ENSP00000225275.3, ENST00000225275.4
      Conserved Domains (1) summary
      cd09824
      Location:316728
      myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      58269855..58280935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      59137736..59148814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)