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    ZNF334 zinc finger protein 334 [ Homo sapiens (human) ]

    Gene ID: 55713, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF334provided by HGNC
    Official Full Name
    zinc finger protein 334provided by HGNC
    Primary source
    HGNC:HGNC:15806
    See related
    Ensembl:ENSG00000198185 MIM:621017; AllianceGenome:HGNC:15806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in ovary (RPKM 2.5), brain (RPKM 1.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF334 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46462313..46513559, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (48199760..48249707, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45128269..45142198, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:45034435-45035064 and GRCh37_chr20:45035065-45035694 Neighboring gene uncharacterized LOC105372633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17973 Neighboring gene NANOG hESC enhancer GRCh37_chr20:45052681-45053240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45087277-45087817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45087818-45088357 Neighboring gene zinc finger protein 663, pseudogene Neighboring gene makorin ring finger protein 7, pseudogene Neighboring gene zinc finger protein 840, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45142238-45142472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45173599-45174450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17976 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45197011-45197512 Neighboring gene solute carrier family 13 member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45211603-45212425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45212426-45213247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17977 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:45250755-45251328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45259736-45260484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45260485-45261231 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45302100-45302256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45303169-45303683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45311939-45312450 Neighboring gene TP53 regulating kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth. Yang B, et al. Cell Death Dis, 2023 Mar 25. PMID 36966142, Free PMC Article
    2. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334. Sun D, et al. Cell Death Dis, 2022 May 9. PMID 35534462, Free PMC Article
    3. Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/β-catenin signaling axis. Cheng Z, et al. Cell Mol Life Sci, 2022 May 4. PMID 35507080, Free PMC Article
    4. Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes. Soroczyńska-Cybula M, et al. Immunology, 2011 Jan. PMID 20738421, Free PMC Article
    5. The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people. Henc I, et al. Acta Biochim Pol, 2015. PMID 25738173

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth.
      Title: Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth.
    2. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334.
      Title: DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334.
    3. Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/beta-catenin signaling axis.
      Title: Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/β-catenin signaling axis.
    4. results obtained in vitro for helper lymphocytes of healthy individuals seem to mimic the regulatory effect of TNFalpha on the expression of ZNF334 in the cells of RA patients
      Title: The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26175

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 334

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270497.3 → NP_001257426.1  zinc finger protein 334 isoform c

      See identical proteins and their annotated locations for NP_001257426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK095611, AL034424, AL354745, BC026321
      Consensus CDS
      CCDS74736.1
      UniProtKB/TrEMBL
      A0A087X1P4
      Related
      ENSP00000485779.1, ENST00000625284.2
      Conserved Domains (3) summary
      smart00349
      Location:9 → 69
      KRAB; krueppel associated box
      COG5048
      Location:318 → 673
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001353813.2 → NP_001340742.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745, AL833936, BC026321, DA080528
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001353814.2 → NP_001340743.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001353815.2 → NP_001340744.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001353816.2 → NP_001340745.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001353817.2 → NP_001340746.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001353818.2 → NP_001340747.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001353819.2 → NP_001340748.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001353820.2 → NP_001340749.1  zinc finger protein 334 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      Conserved Domains (3) summary
      COG5048
      Location:314 → 669
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:45 → 65
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    10. NM_001353821.2 → NP_001340750.1  zinc finger protein 334 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      Consensus CDS
      CCDS74736.1
      UniProtKB/TrEMBL
      A0A087X1P4
      Conserved Domains (3) summary
      smart00349
      Location:9 → 69
      KRAB; krueppel associated box
      COG5048
      Location:318 → 673
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_001353822.2 → NP_001340751.1  zinc finger protein 334 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      Consensus CDS
      CCDS74736.1
      UniProtKB/TrEMBL
      A0A087X1P4
      Conserved Domains (3) summary
      smart00349
      Location:9 → 69
      KRAB; krueppel associated box
      COG5048
      Location:318 → 673
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001353823.2 → NP_001340752.1  zinc finger protein 334 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      Consensus CDS
      CCDS74736.1
      UniProtKB/TrEMBL
      A0A087X1P4
      Conserved Domains (3) summary
      smart00349
      Location:9 → 69
      KRAB; krueppel associated box
      COG5048
      Location:318 → 673
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. NM_001353824.2 → NP_001340753.1  zinc finger protein 334 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      Consensus CDS
      CCDS33480.1
      UniProtKB/Swiss-Prot
      Q5T6U2, Q9HCZ1, Q9NVW4
      Related
      ENSP00000510334.1, ENST00000692313.1
      Conserved Domains (3) summary
      smart00349
      Location:10 → 70
      KRAB; krueppel associated box
      COG5048
      Location:319 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. NM_001353825.2 → NP_001340754.1  zinc finger protein 334 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      Consensus CDS
      CCDS86959.1
      UniProtKB/TrEMBL
      Q8N3P8
      Related
      ENSP00000473194.1, ENST00000593880.1
      Conserved Domains (3) summary
      COG5048
      Location:342 → 697
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:73 → 93
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    15. NM_001353826.2 → NP_001340755.1  zinc finger protein 334 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745
      Conserved Domains (3) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      COG5048
      Location:326 → 681
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:246 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. NM_018102.6 → NP_060572.3  zinc finger protein 334 isoform a

      See identical proteins and their annotated locations for NP_060572.3

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745, BC024177, BC026321
      Consensus CDS
      CCDS33480.1
      UniProtKB/Swiss-Prot
      Q5T6U2, Q9HCZ1, Q9NVW4
      Related
      ENSP00000255129.5, ENST00000347606.8
      Conserved Domains (3) summary
      smart00349
      Location:10 → 70
      KRAB; krueppel associated box
      COG5048
      Location:319 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. NM_199441.3 → NP_955473.1  zinc finger protein 334 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL034424, AL354745, BC026321
      UniProtKB/TrEMBL
      A0A0B4J1Y0
      Related
      ENSP00000402582.1, ENST00000457685.6
      Conserved Domains (3) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:281 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      46462313..46513559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440281.1 → XP_047296237.1  zinc finger protein 334 isoform X4

      UniProtKB/Swiss-Prot
      Q5T6U2, Q9HCZ1, Q9NVW4

    2. XM_017027937.2 → XP_016883426.1  zinc finger protein 334 isoform X3

      Conserved Domains (3) summary
      smart00349
      Location:33 → 93
      KRAB; krueppel associated box
      COG5048
      Location:342 → 697
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_047440282.1 → XP_047296238.1  zinc finger protein 334 isoform X5

      UniProtKB/TrEMBL
      A0A087X1P4
      Related
      ENSP00000484362.1, ENST00000615481.4

    4. XM_047440280.1 → XP_047296236.1  zinc finger protein 334 isoform X2

    5. XM_047440279.1 → XP_047296235.1  zinc finger protein 334 isoform X1

      UniProtKB/TrEMBL
      Q8N3P8

    6. XM_047440284.1 → XP_047296240.1  zinc finger protein 334 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J1Y0

    7. XM_047440283.1 → XP_047296239.1  zinc finger protein 334 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J1Y0

    RNA

    1. XR_007067464.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      48199760..48249707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323668.1 → XP_054179643.1  zinc finger protein 334 isoform X5

      UniProtKB/TrEMBL
      A0A087X1P4

    2. XM_054323667.1 → XP_054179642.1  zinc finger protein 334 isoform X4

      UniProtKB/Swiss-Prot
      Q5T6U2, Q9HCZ1, Q9NVW4

    3. XM_054323666.1 → XP_054179641.1  zinc finger protein 334 isoform X2

    4. XM_054323665.1 → XP_054179640.1  zinc finger protein 334 isoform X1

      UniProtKB/TrEMBL
      Q8N3P8

    5. XM_054323669.1 → XP_054179644.1  zinc finger protein 334 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J1Y0

    RNA

    1. XR_008485270.1 RNA Sequence

    2. XR_008485272.1 RNA Sequence

    3. XR_008485271.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCZ1.2 GenPept UniProtKB/Swiss-Prot:Q9HCZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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