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    Slc25a33 solute carrier family 25 member 33 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a33provided by RGD
    Official Full Name
    solute carrier family 25 member 33provided by RGD
    Primary source
    RGD:1583942
    See related
    EnsemblRapid:ENSRNOG00000016949 AllianceGenome:RGD:1583942
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pyrimidine nucleotide transmembrane transporter activity. Predicted to be involved in several processes, including cellular response to peptide hormone stimulus; mitochondria-nucleus signaling pathway; and mitochondrion organization. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A33 (solute carrier family 25 member 33). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 158.8), Lung (RPKM 104.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a33 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (165478070..165518186, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (160195040..160219961, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (166701463..166726794, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Neighboring gene uncharacterized LOC120103039 Neighboring gene transmembrane protein 201 Neighboring gene uncharacterized LOC102548220 Neighboring gene ribosomal protein S2, pseudogene 44 Neighboring gene uncharacterized LOC120103040 Neighboring gene uncharacterized LOC102548366

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells. Favre C, et al. Oncogene, 2010 Jul 8. PMID 20453889
    2. The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. Di Noia MA, et al. J Biol Chem, 2014 Nov 28. PMID 25320081, Free PMC Article
    3. The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Floyd S, et al. Mol Biol Cell, 2007 Sep. PMID 17596519, Free PMC Article
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pyrimidine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin-like growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondria-nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleotide import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 25 member 33
    Names
    solute carrier family 25 (pyrimidine nucleotide carrier), member 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127574.1 → NP_001121046.1  solute carrier family 25 member 33

      See identical proteins and their annotated locations for NP_001121046.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167066
      UniProtKB/TrEMBL
      B2RZ89
      Related
      ENSRNOP00000099553.1, ENSRNOT00000022799.8
      Conserved Domains (2) summary
      PTZ00169
      Location:6 → 316
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:7 → 123
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      165478070..165518186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288452.1 → XP_063144522.1  solute carrier family 25 member 33 isoform X1

      UniProtKB/TrEMBL
      B2RZ89

    2. XM_063288453.1 → XP_063144523.1  solute carrier family 25 member 33 isoform X1

      UniProtKB/TrEMBL
      B2RZ89

    3. XM_063288454.1 → XP_063144524.1  solute carrier family 25 member 33 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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