Rb1cc1 RB1-inducible coiled-coil 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rb1cc1provided by MGI
Official Full Name: RB1-inducible coiled-coil 1provided by MGI
Primary source: MGI:MGI:1341850
See related: Ensembl:ENSMUSG00000025907 AllianceGenome:MGI:1341850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cc1; FIP200; LaXp180; 2900055E04Rik; 5930404L04Rik
Summary: Enables protein kinase binding activity. Involved in several processes, including autophagosome assembly; positive regulation of autophagy; and regulation of protein lipidation. Acts upstream of or within several processes, including defense response to symbiont; positive regulation of cell size; and regulation of signal transduction. Located in autophagosome membrane; nucleus; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including cerebral cortex; ganglia; musculoskeletal system; oocyte; and trunk paraxial mesenchyme. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 10.4), cerebellum adult (RPKM 5.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A1; 1 1.89 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (6284858..6346599)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (6214634..6276375)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy in PDGFRalpha+ mesenchymal cells is essential for intestinal stem cell survival.
Title: Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival.
Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.
Title: Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.
FIP200 restricts RNA virus infection by facilitating RIG-I activation.
Title: FIP200 restricts RNA virus infection by facilitating RIG-I activation.
The autophagy protein, FIP200 (RB1CC1) mediates progesterone responses governing uterine receptivity and decidualizationdagger.
Title: The autophagy protein, FIP200 (RB1CC1) mediates progesterone responses governing uterine receptivity and decidualization†.
FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.
Title: FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.
Overexpression of miR-224-3p alleviates apoptosis from cerebral ischemia reperfusion injury by targeting FIP200.
Title: Overexpression of miR-224-3p alleviates apoptosis from cerebral ischemia reperfusion injury by targeting FIP200.
Genetic FIP200 protein deletion impairs autophagy induction and causes T cell apoptosis.
Title: Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.
Suggest that autophagy gene FIP200 plays a crucial role in regulating neurogenesis and restricting local immune response in postnatal neural stem cells through non-cell autonomous mechanisms.
Title: Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.
residues 582-585 (LQFL) in FIP200 are required for interaction with Atg13, and mutation of these residues to AAAA (designated the FIP200-4A mutant) abolished its canonical autophagy function in vitro.
Title: Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium
Title: Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein lipidation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Atg1/ULK1 kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Atg1/ULK1 kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Atg1/ULK1 kinase complex	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RB1-inducible coiled-coil protein 1

Names: 200 kDa FAK family kinase-interacting protein; FAK family kinase-interacting protein of 200 kDa; coiled-coil-forming protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009826.4 → NP_033956.2 RB1-inducible coiled-coil protein 1

See identical proteins and their annotated locations for NP_033956.2

Status: VALIDATED

Source sequence(s)

AB070619, AK033709, AK041038, CN720888

Consensus CDS

CCDS35507.1

UniProtKB/Swiss-Prot

E9QLQ2, Q3TXX2, Q61384, Q8BRY9, Q9ESK9, Q9JK14

UniProtKB/TrEMBL

B2RX00

Related

ENSMUSP00000027040.7, ENSMUST00000027040.13

Conserved Domains (4) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam04108
Location:312 → 537

APG17; Autophagy protein Apg17

pfam10377
Location:1456 → 1582

ATG11; Autophagy-related protein 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

6284858..6346599

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238338.3 → XP_011236640.1 RB1-inducible coiled-coil protein 1 isoform X1

See identical proteins and their annotated locations for XP_011236640.1

UniProtKB/TrEMBL

B2RX00

Conserved Domains (3) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam10377
Location:1506 → 1600

ATG11; Autophagy-related protein 11
XM_011238341.4 → XP_011236643.1 RB1-inducible coiled-coil protein 1 isoform X2

UniProtKB/TrEMBL

B2RX00

Conserved Domains (3) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam10377
Location:1506 → 1597

ATG11; Autophagy-related protein 11
XM_006495443.5 → XP_006495506.1 RB1-inducible coiled-coil protein 1 isoform X4

UniProtKB/TrEMBL

B2RX00

Conserved Domains (3) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam10377
Location:1456 → 1579

ATG11; Autophagy-related protein 11
XM_036156298.1 → XP_036012191.1 RB1-inducible coiled-coil protein 1 isoform X5

UniProtKB/TrEMBL

B2RX00

Conserved Domains (2) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
XM_036156334.1 → XP_036012227.1 RB1-inducible coiled-coil protein 1 isoform X7

UniProtKB/TrEMBL

F7CC56

Conserved Domains (2) summary

COG0419
Location:644 → 1175

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

pfam10377
Location:1258 → 1384

ATG11; Autophagy-related protein 11
XM_036156326.1 → XP_036012219.1 RB1-inducible coiled-coil protein 1 isoform X6

UniProtKB/TrEMBL

F7CC56

Conserved Domains (2) summary

COG0419
Location:644 → 1175

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

pfam10377
Location:1308 → 1402

ATG11; Autophagy-related protein 11
XM_011238339.2 → XP_011236641.1 RB1-inducible coiled-coil protein 1 isoform X1

See identical proteins and their annotated locations for XP_011236641.1

UniProtKB/TrEMBL

B2RX00

Conserved Domains (3) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam10377
Location:1506 → 1600

ATG11; Autophagy-related protein 11
XM_011238340.2 → XP_011236642.1 RB1-inducible coiled-coil protein 1 isoform X1

See identical proteins and their annotated locations for XP_011236642.1

UniProtKB/TrEMBL

B2RX00

Conserved Domains (3) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam10377
Location:1506 → 1600

ATG11; Autophagy-related protein 11
XM_036156270.1 → XP_036012163.1 RB1-inducible coiled-coil protein 1 isoform X3

UniProtKB/Swiss-Prot

E9QLQ2, Q3TXX2, Q61384, Q8BRY9, Q9ESK9, Q9JK14

UniProtKB/TrEMBL

B2RX00

Related

ENSMUSP00000125348.2, ENSMUST00000161327.8

Conserved Domains (4) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam04108
Location:312 → 537

APG17; Autophagy protein Apg17

pfam10377
Location:1456 → 1582

ATG11; Autophagy-related protein 11
XM_036156247.1 → XP_036012140.1 RB1-inducible coiled-coil protein 1 isoform X1

UniProtKB/TrEMBL

B2RX00

Conserved Domains (3) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam10377
Location:1506 → 1600

ATG11; Autophagy-related protein 11
XM_036156243.1 → XP_036012136.1 RB1-inducible coiled-coil protein 1 isoform X1

UniProtKB/TrEMBL

B2RX00

Conserved Domains (3) summary

COG0419
Location:842 → 1373

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd17060
Location:2 → 76

Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins

pfam10377
Location:1506 → 1600

ATG11; Autophagy-related protein 11