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    itsn1 intersectin 1 (SH3 domain protein) [ Sander lucioperca (pikeperch) ]

    Gene ID: 116061727, updated on 21-Aug-2024

    Summary

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    Gene symbol
    itsn1
    Gene description
    intersectin 1 (SH3 domain protein)
    See related
    EnsemblRapid:ENSSLUG00000010021
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sander lucioperca
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Perciformes; Percoidei; Percidae; Luciopercinae; Sander
    Orthologs
    human zebrafish all
    NEW
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    Genomic context

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    See itsn1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    101 current SLUC_FBN_1.2 (GCF_008315115.2) 15 NC_050187.1 (31168178..31224579, complement)
    100 previous assembly SLUC_FBN_1 (GCF_008315115.1) Unplaced Scaffold NW_022172946.1 (2137204..2193651)

    Chromosome 15 - NC_050187.1Genomic Context describing neighboring genes Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase b Neighboring gene uncharacterized LOC116061731 Neighboring gene uncharacterized protein PB18E9.04c Neighboring gene crystallin, zeta (quinone reductase)-like 1 Neighboring gene SET domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intersectin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sander lucioperca Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference SLUC_FBN_1.2 Primary Assembly

    Genomic

    1. NC_050187.1 Reference SLUC_FBN_1.2 Primary Assembly

      Range
      31168178..31224579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_035992072.1 → XP_035847965.1  intersectin-1 isoform X11

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Related
      ENSSLUP00000029433.2, ENSSLUT00000030371.2
      Conserved Domains (10) summary
      cd08375
      Location:1621 → 1755
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:942 → 994
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1198 → 1250
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1110 → 1174
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1277 → 1460
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 599
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:824 → 942
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1479 → 1621
      PH_13; Pleckstrin homology domain
      cl17036
      Location:770 → 824
      SH3; Src Homology 3 domain superfamily

    2. XM_035992071.1 → XP_035847964.1  intersectin-1 isoform X10

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1626 → 1760
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:947 → 999
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1203 → 1255
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1115 → 1179
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1282 → 1465
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 599
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:829 → 947
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1484 → 1626
      PH_13; Pleckstrin homology domain
      cl17036
      Location:770 → 829
      SH3; Src Homology 3 domain superfamily

    3. XM_035992070.1 → XP_035847963.1  intersectin-1 isoform X9

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1630 → 1764
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:947 → 999
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1207 → 1259
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1115 → 1179
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1286 → 1469
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 599
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:829 → 947
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1488 → 1630
      PH_13; Pleckstrin homology domain
      cl17036
      Location:770 → 829
      SH3; Src Homology 3 domain superfamily

    4. XM_035992069.1 → XP_035847962.1  intersectin-1 isoform X8

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1653 → 1787
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:970 → 1022
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1230 → 1282
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1138 → 1202
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1309 → 1492
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 625
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:852 → 970
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1511 → 1653
      PH_13; Pleckstrin homology domain
      cl17036
      Location:798 → 852
      SH3; Src Homology 3 domain superfamily

    5. XM_035992068.1 → XP_035847961.1  intersectin-1 isoform X7

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1658 → 1792
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:975 → 1027
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1235 → 1287
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1143 → 1207
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1314 → 1497
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 625
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:857 → 975
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1516 → 1658
      PH_13; Pleckstrin homology domain
      cl17036
      Location:798 → 857
      SH3; Src Homology 3 domain superfamily

    6. XM_035992066.1 → XP_035847959.1  intersectin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1678 → 1812
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:995 → 1047
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1255 → 1307
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1163 → 1227
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1334 → 1517
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:877 → 995
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1536 → 1678
      PH_13; Pleckstrin homology domain
      cl17036
      Location:823 → 877
      SH3; Src Homology 3 domain superfamily

    7. XM_035992063.1 → XP_035847956.1  intersectin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1683 → 1817
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:1000 → 1052
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1260 → 1312
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1168 → 1232
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1339 → 1522
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:882 → 1000
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1541 → 1683
      PH_13; Pleckstrin homology domain
      cl17036
      Location:823 → 882
      SH3; Src Homology 3 domain superfamily

    8. XM_035992067.1 → XP_035847960.1  intersectin-1 isoform X6

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (11) summary
      cd08375
      Location:1675 → 1809
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:996 → 1048
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1252 → 1304
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11987
      Location:824 → 878
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11993
      Location:1164 → 1228
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1331 → 1514
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:878 → 996
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1533 → 1675
      PH_13; Pleckstrin homology domain
      cl17036
      Location:1094 → 1145
      SH3; Src Homology 3 domain superfamily

    9. XM_035992065.1 → XP_035847958.1  intersectin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1679 → 1813
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:996 → 1048
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1256 → 1308
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1164 → 1228
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1335 → 1518
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:878 → 996
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1537 → 1679
      PH_13; Pleckstrin homology domain
      cl17036
      Location:824 → 878
      SH3; Src Homology 3 domain superfamily

    10. XM_035992064.1 → XP_035847957.1  intersectin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1680 → 1814
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:1001 → 1053
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1257 → 1309
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1169 → 1233
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1336 → 1519
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:883 → 1001
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1538 → 1680
      PH_13; Pleckstrin homology domain
      cl17036
      Location:824 → 883
      SH3; Src Homology 3 domain superfamily

    11. XM_035992062.1 → XP_035847955.1  intersectin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C9YTR6
      Conserved Domains (10) summary
      cd08375
      Location:1684 → 1818
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:16 → 105
      EH; Eps15 homology domain
      cd11837
      Location:1001 → 1053
      SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
      cd11840
      Location:1261 → 1313
      SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
      cd11993
      Location:1169 → 1233
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd00160
      Location:1340 → 1523
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:430 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:883 → 1001
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1542 → 1684
      PH_13; Pleckstrin homology domain
      cl17036
      Location:824 → 883
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
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