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    Il1r2 interleukin 1 receptor, type II [ Mus musculus (house mouse) ]

    Gene ID: 16178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il1r2provided by MGI
    Official Full Name
    interleukin 1 receptor, type IIprovided by MGI
    Primary source
    MGI:MGI:96546
    See related
    Ensembl:ENSMUSG00000026073 AllianceGenome:MGI:96546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD121b; Il1r-2
    Summary
    Enables interleukin-1 binding activity and interleukin-1 receptor activity. Acts upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm. Is expressed in several structures, including gut; pituitary gland; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in aggressive periodontitis; esophageal cancer; lung cancer; and organ system cancer. Orthologous to human IL1R2 (interleukin 1 receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 4.5), mammary gland adult (RPKM 1.6) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il1r2 in Genome Data Viewer
    Location:
    1 B; 1 18.65 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40123872..40164390)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40084692..40125230)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00730 Neighboring gene predicted gene, 35600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39952403-39952658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39953411-39953598 Neighboring gene STARR-seq mESC enhancer starr_00731 Neighboring gene STARR-seq mESC enhancer starr_00732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39991996-39992105 Neighboring gene STARR-positive B cell enhancer ABC_E9463 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene VISTA enhancer mm1333 Neighboring gene STARR-positive B cell enhancer mm9_chr1:40142581-40142881 Neighboring gene STARR-seq mESC enhancer starr_00736 Neighboring gene predicted gene, 16894 Neighboring gene predicted gene, 35741 Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene interleukin 1 receptor, type I Neighboring gene STARR-seq mESC enhancer starr_00738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription. Whitley SK, et al. J Biol Chem, 2018 Oct 12. PMID 30093408, Free PMC Article
    2. Differential expression of interleukin 1 receptor type II during mouse decidualization. Zhang XH, et al. Reprod Sci, 2012 Sep. PMID 22556012
    3. Distribution of type I interleukin-1 receptor messenger RNA in testis: an in situ histochemical study in the mouse. Cunningham ET Jr, et al. Neuroendocrinology, 1992 Jul. PMID 1386414
    4. Interleukin-1 receptors: cloning studies and role in central nervous system disorders. Loddick SA, et al. Brain Res Brain Res Rev, 1998 May. PMID 9651547
    5. Murine T helper cell-2 lymphocytes express type I and type II IL-1 receptors, but only the type I receptor mediates costimulatory activity. McKean DJ, et al. J Immunol, 1993 Oct 1. PMID 8376789

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.
      Title: Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.
    2. IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1alpha/PFKFB3 pathway.
      Title: IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1α/PFKFB3 pathway.
    3. Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
      Title: Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
    4. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
      Title: Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
    5. Our studies demonstrate that Zbtb38 forms a molecular bridge between an arthritis-associated epimutation (DNA hypomethylation in Zbtb38 promoter) and transcriptional silencing of the IL1r2 gene in B cells. In this way, disease-associated DNA hypomethylation can support autoimmune arthritis by interfering with an anti-inflammatory pathway.
      Title: Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis.
    6. Il1r2 encourages STAT3 to bind to cis-elements that regulate expression of interleukin-17.
      Title: IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription.
    7. Thus, we show that IL-1R2 is harmful for the development of colitis, because IL-1R2 promotes the growth of proinflammatory intestinal microbiota by suppressing IL-1beta-induced AMP production.
      Title: IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.
    8. present study demonstrated the ability of Staphylococcus aureus to induce IL-1RII shedding in myeloid cells
      Title: Staphylococcus aureus Induces Shedding of IL-1RII in Monocytes and Neutrophils.
    9. Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1- and neutrophil-dependent tissue inflammation
      Title: Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses.
    10. Data indicate that a disintegrin and metallopeptidase domain 17 (ADAM17) regulates interleukin (IL)-1 signaling via cleavage of IL-1 receptor type 2 (IL-1R2).
      Title: ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (9)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-1 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-1 receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-1, type II, blocking receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-1 alpha production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-1-mediated signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor type 2
    Names
    CD121 antigen-like family member B
    IL-1 receptor beta chain
    IL-1 type II receptor
    IL-1R-2
    IL-1R-beta
    IL-1RT-2
    IL-1RT2
    interleukin-1 receptor beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360800.1 → NP_001347729.1  interleukin-1 receptor type 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC161534
      Conserved Domains (1) summary
      PHA02785
      Location:54 → 382
      PHA02785; IL-beta-binding protein; Provisional

    2. NM_001360801.1 → NP_001347730.1  interleukin-1 receptor type 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161534, BC032962
      UniProtKB/TrEMBL
      Q8K084
      Conserved Domains (2) summary
      PHA02785
      Location:1 → 234
      PHA02785; IL-beta-binding protein; Provisional
      cl11960
      Location:18 → 112
      Ig; Immunoglobulin domain

    3. NM_010555.5 → NP_034685.1  interleukin-1 receptor type 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034685.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161534, AK132264
      Consensus CDS
      CCDS14909.1
      UniProtKB/Swiss-Prot
      P27931
      UniProtKB/TrEMBL
      Q4FK69
      Related
      ENSMUSP00000027243.8, ENSMUST00000027243.13
      Conserved Domains (1) summary
      PHA02785
      Location:36 → 364
      PHA02785; IL-beta-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      40123872..40164390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317722.3 → XP_017173211.1  interleukin-1 receptor type 2 isoform X1

      Conserved Domains (1) summary
      PHA02785
      Location:54 → 382
      PHA02785; IL-beta-binding protein; Provisional

    2. XM_011238437.4 → XP_011236739.1  interleukin-1 receptor type 2 isoform X2

      See identical proteins and their annotated locations for XP_011236739.1

      UniProtKB/Swiss-Prot
      P27931
      UniProtKB/TrEMBL
      Q4FK69
      Conserved Domains (1) summary
      PHA02785
      Location:36 → 364
      PHA02785; IL-beta-binding protein; Provisional

    3. XM_030250758.2 → XP_030106618.1  interleukin-1 receptor type 2 isoform X2

      UniProtKB/Swiss-Prot
      P27931
      UniProtKB/TrEMBL
      Q4FK69
      Conserved Domains (1) summary
      PHA02785
      Location:36 → 364
      PHA02785; IL-beta-binding protein; Provisional

    4. XM_011238438.3 → XP_011236740.1  interleukin-1 receptor type 2 isoform X2

      See identical proteins and their annotated locations for XP_011236740.1

      UniProtKB/Swiss-Prot
      P27931
      UniProtKB/TrEMBL
      Q4FK69
      Conserved Domains (1) summary
      PHA02785
      Location:36 → 364
      PHA02785; IL-beta-binding protein; Provisional

    5. XM_011238440.4 → XP_011236742.1  interleukin-1 receptor type 2 isoform X2

      See identical proteins and their annotated locations for XP_011236742.1

      UniProtKB/Swiss-Prot
      P27931
      UniProtKB/TrEMBL
      Q4FK69
      Conserved Domains (1) summary
      PHA02785
      Location:36 → 364
      PHA02785; IL-beta-binding protein; Provisional

    6. XM_036162222.1 → XP_036018115.1  interleukin-1 receptor type 2 isoform X2

      UniProtKB/Swiss-Prot
      P27931
      UniProtKB/TrEMBL
      Q4FK69
      Conserved Domains (1) summary
      PHA02785
      Location:36 → 364
      PHA02785; IL-beta-binding protein; Provisional

    7. XM_006495726.4 → XP_006495789.1  interleukin-1 receptor type 2 isoform X3

      UniProtKB/TrEMBL
      Q8K084
      Conserved Domains (2) summary
      PHA02785
      Location:1 → 234
      PHA02785; IL-beta-binding protein; Provisional
      cl11960
      Location:18 → 112
      Ig; Immunoglobulin domain

    RNA

    1. XR_003952769.2 RNA Sequence

    2. XR_003952762.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27931.1 GenPept UniProtKB/Swiss-Prot:P27931

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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