Coro6 coronin 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coro6provided by MGI
Official Full Name: coronin 6provided by MGI
Primary source: MGI:MGI:2183448
See related: Ensembl:ENSMUSG00000020836 AllianceGenome:MGI:2183448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. Is expressed in bladder; heart; intestine; and skeletal muscle. Orthologous to human CORO6 (coronin 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 120.1), cortex adult (RPKM 32.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.58 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (77353149..77361310)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (77462321..77470484)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction
Title: Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: coronin-6

Names: clipin E; coronin 6/clipin E type D; coronin, actin binding protein 6; coronin-like protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368670.1 → NP_001355599.1 coronin-6 isoform D

Status: VALIDATED

Source sequence(s)

AL607072

Consensus CDS

CCDS88194.1

UniProtKB/TrEMBL

B9EIZ7

Related

ENSMUSP00000056862.6, ENSMUST00000052515.12

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 426

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_139128.2 → NP_624354.1 coronin-6 isoform A

See identical proteins and their annotated locations for NP_624354.1

Status: VALIDATED

Source sequence(s)

AL607072

Consensus CDS

CCDS25077.1

UniProtKB/Swiss-Prot

Q3TZ14, Q5F262, Q5F263, Q5F264, Q5F265, Q920M3, Q920M4, Q920M5

Related

ENSMUSP00000021190.3, ENSMUST00000021190.9

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 465

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_139129.2 → NP_624355.1 coronin-6 isoform C

See identical proteins and their annotated locations for NP_624355.1

Status: VALIDATED

Source sequence(s)

AL607072

Consensus CDS

CCDS25078.1

UniProtKB/Swiss-Prot

Q920M5

Related

ENSMUSP00000078703.3, ENSMUST00000079770.3

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 425

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_139130.3 → NP_624356.1 coronin-6 isoform B

See identical proteins and their annotated locations for NP_624356.1

Status: VALIDATED

Source sequence(s)

AL607072

Consensus CDS

CCDS25079.1

UniProtKB/Swiss-Prot

Q920M5

Related

ENSMUSP00000104028.3, ENSMUST00000108391.9

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 465

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

NR_160865.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL607072

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

77353149..77361310

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532940.3 → XP_006533003.1 coronin-6 isoform X1

See identical proteins and their annotated locations for XP_006533003.1

UniProtKB/Swiss-Prot

Q920M5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 466

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532938.4 → XP_006533001.1 coronin-6 isoform X2

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 466

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532945.4 → XP_006533008.1 coronin-6 isoform X4

See identical proteins and their annotated locations for XP_006533008.1

UniProtKB/Swiss-Prot

Q3TZ14, Q5F262, Q5F263, Q5F264, Q5F265, Q920M3, Q920M4, Q920M5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 465

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036156578.1 → XP_036012471.1 coronin-6 isoform X1

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 466

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532944.3 → XP_006533007.1 coronin-6 isoform X3

See identical proteins and their annotated locations for XP_006533007.1

UniProtKB/Swiss-Prot

Q920M5

Related

ENSMUSP00000099551.2, ENSMUST00000102493.8

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 465

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017314462.3 → XP_017169951.2 coronin-6 isoform X2

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 466

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532941.3 → XP_006533004.1 coronin-6 isoform X1

See identical proteins and their annotated locations for XP_006533004.1

UniProtKB/Swiss-Prot

Q920M5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 466

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532942.3 → XP_006533005.1 coronin-6 isoform X1

See identical proteins and their annotated locations for XP_006533005.1

UniProtKB/Swiss-Prot

Q920M5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 466

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017314461.3 → XP_017169950.1 coronin-6 isoform X1

UniProtKB/Swiss-Prot

Q920M5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 466

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532946.3 → XP_006533009.1 coronin-6 isoform X5

See identical proteins and their annotated locations for XP_006533009.1

UniProtKB/TrEMBL

B9EIZ7

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 426

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532947.4 → XP_006533010.1 coronin-6 isoform X6

See identical proteins and their annotated locations for XP_006533010.1

UniProtKB/Swiss-Prot

Q920M5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 425

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...