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    Ace3 angiotensin I converting enzyme 3 [ Mus musculus (house mouse) ]

    Gene ID: 217246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ace3provided by MGI
    Official Full Name
    angiotensin I converting enzyme 3provided by MGI
    Primary source
    MGI:MGI:3644400
    See related
    Ensembl:ENSMUSG00000101605 AllianceGenome:MGI:3644400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG217246
    Summary
    Predicted to enable metallopeptidase activity and peptidyl-dipeptidase activity. Predicted to be involved in positive regulation of systemic arterial blood pressure and regulation of systemic arterial blood pressure by renin-angiotensin. Located in acrosomal vesicle. Orthologous to human ACE3P (angiotensin I converting enzyme 3, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 16.2) See more
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    Genomic context

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    See Ace3 in Genome Data Viewer
    Location:
    11 E1; 11 68.86 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105885424..105898376)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105994588..106007550)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytochrome b-561 Neighboring gene predicted gene 9910 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme Neighboring gene predicted gene, 35971 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E43 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy. Yu CJ, et al. J Am Heart Assoc, 2016 Feb 18. PMID 26892527, Free PMC Article
    2. Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. Inoue N, et al. PLoS One, 2010 Apr 22. PMID 20421979, Free PMC Article
    3. Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. Rella M, et al. BMC Genomics, 2007 Jun 27. PMID 17597519, Free PMC Article
    4. Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice. Weiss D, et al. Atherosclerosis, 2010 Apr. PMID 19880118, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACE3 inhibits pressure overload-induced cardiac hypertrophy by blocking the MEK-ERK1/2 signaling pathway.
      Title: Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy.
    2. identified an IZUMO1-interacting protein in sperm, which was identified as testis specific ACE homologue ACE3.
      Title: Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse.
    3. In the ACE 3/3 animals, atherosclerotic lesion area was not different from wild type controls despite reduced plasma ACE activity.
      Title: Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiotensin-converting enzyme-like protein Ace3
    Names
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
    NP_001094923.2
    XP_006533116.1
    XP_006533117.1
    XP_006533119.1
    XP_006533121.1
    XP_006533122.1
    XP_006533123.1
    XP_030101747.1
    XP_030101748.1
    XP_030101749.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101453.3 → NP_001094923.2  angiotensin-converting enzyme-like protein Ace3 precursor

      See identical proteins and their annotated locations for NP_001094923.2

      Status: VALIDATED

      Source sequence(s)
      AL596331
      Consensus CDS
      CCDS59570.1
      UniProtKB/Swiss-Prot
      D0G895
      Related
      ENSMUSP00000140827.2, ENSMUST00000190995.2
      Conserved Domains (1) summary
      pfam01401
      Location:33 → 609
      Peptidase_M2; Angiotensin-converting enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105885424..105898376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533054.5 → XP_006533117.1  angiotensin-converting enzyme-like protein Ace3 isoform X2

      Conserved Domains (1) summary
      pfam01401
      Location:51 → 635
      Peptidase_M2; Angiotensin-converting enzyme

    2. XM_030245887.2 → XP_030101747.1  angiotensin-converting enzyme-like protein Ace3 isoform X4

      Conserved Domains (1) summary
      pfam01401
      Location:51 → 587
      Peptidase_M2; Angiotensin-converting enzyme

    3. XM_006533056.5 → XP_006533119.1  angiotensin-converting enzyme-like protein Ace3 isoform X3

      Conserved Domains (1) summary
      pfam01401
      Location:51 → 618
      Peptidase_M2; Angiotensin-converting enzyme

    4. XM_006533053.5 → XP_006533116.1  angiotensin-converting enzyme-like protein Ace3 isoform X1

      Conserved Domains (1) summary
      pfam01401
      Location:51 → 647
      Peptidase_M2; Angiotensin-converting enzyme

    5. XM_006533058.5 → XP_006533121.1  angiotensin-converting enzyme-like protein Ace3 isoform X7

      Conserved Domains (1) summary
      pfam01401
      Location:51 → 595
      Peptidase_M2; Angiotensin-converting enzyme

    6. XM_006533059.5 → XP_006533122.1  angiotensin-converting enzyme-like protein Ace3 isoform X8

      Conserved Domains (1) summary
      pfam01401
      Location:51 → 594
      Peptidase_M2; Angiotensin-converting enzyme

    7. XM_006533060.5 → XP_006533123.1  angiotensin-converting enzyme-like protein Ace3 isoform X9

      Conserved Domains (1) summary
      cl14813
      Location:51 → 397
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    8. XM_030245888.2 → XP_030101748.1  angiotensin-converting enzyme-like protein Ace3 isoform X5

      Conserved Domains (1) summary
      pfam01401
      Location:26 → 561
      Peptidase_M2; Angiotensin-converting enzyme

    9. XM_030245889.2 → XP_030101749.1  angiotensin-converting enzyme-like protein Ace3 isoform X6

      Conserved Domains (1) summary
      pfam01401
      Location:26 → 549
      Peptidase_M2; Angiotensin-converting enzyme

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_012394.1: Suppressed sequence

      Description
      NG_012394.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0G895.1 GenPept UniProtKB/Swiss-Prot:D0G895

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