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    Bahcc1 BAH domain and coiled-coil containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 268515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bahcc1provided by MGI
    Official Full Name
    BAH domain and coiled-coil containing 1provided by MGI
    Primary source
    MGI:MGI:2679272
    See related
    Ensembl:ENSMUSG00000039741 AllianceGenome:MGI:2679272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930044J06
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within chromatin organization; locomotory behavior; and neuron differentiation. Is expressed in central nervous system and retina. Orthologous to human BAHCC1 (BAH domain and coiled-coil containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.0), CNS E14 (RPKM 5.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bahcc1 in Genome Data Viewer
    Location:
    11 E2; 11 83.96 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120123696..120183123)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120232870..120292297)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11770 Neighboring gene RIKEN cDNA 2900052L18 gene Neighboring gene STARR-seq mESC enhancer starr_31347 Neighboring gene predicted gene 11772 Neighboring gene STARR-seq mESC enhancer starr_31350 Neighboring gene STARR-positive B cell enhancer ABC_E3044 Neighboring gene STARR-positive B cell enhancer ABC_E9383 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120172126-120172235 Neighboring gene VISTA enhancer mm1481 Neighboring gene RIKEN cDNA 0610009L18 gene Neighboring gene microRNA 6935 Neighboring gene actin, gamma, cytoplasmic 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia. Nakamura A, et al. Blood Adv, 2024 May 14. PMID 38452334, Free PMC Article
    2. Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression. Li J, et al. Cell Signal, 2024 Apr. PMID 38290642,
    3. BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Fan H, et al. Nat Genet, 2020 Dec. PMID 33139953, Free PMC Article
    4. Regulation of neuronal commitment in mouse embryonic stem cells by the Reno1/Bahcc1 locus. Hezroni H, et al. EMBO Rep, 2020 Nov 5. PMID 32969152, Free PMC Article
    5. A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. Nakayama M, et al. FASEB J, 2006 Aug. PMID 16807365

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia.
      Title: Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia.
    2. Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression.
      Title: Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1447, MGC79150

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BAH and coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347621.2 → NP_001334550.1  BAH and coiled-coil domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AL928567
      Consensus CDS
      CCDS83943.1
      UniProtKB/Swiss-Prot
      A2AS78, Q0KK52, Q0KK57, Q3TPP4, Q3UHG9, Q3UHR0, Q6GQV4, Q6P9S8, Q6PFC9, Q80UX2
      Related
      ENSMUSP00000112827.2, ENSMUST00000122148.8
      Conserved Domains (2) summary
      cd04714
      Location:2516 → 2635
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:1984 → 2036
      Tudor_3; DNA repair protein Crb2 Tudor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120123696..120183123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249048.3 → XP_011247350.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011247350.1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    2. XM_017314567.2 → XP_017170056.1  BAH and coiled-coil domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2636
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:1985 → 2037
      Tudor_3; DNA repair protein Crb2 Tudor domain

    3. XM_017314566.2 → XP_017170055.1  BAH and coiled-coil domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      cd04714
      Location:2516 → 2679
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:1984 → 2036
      Tudor_3; DNA repair protein Crb2 Tudor domain

    4. XM_036156725.1 → XP_036012618.1  BAH and coiled-coil domain-containing protein 1 isoform X5

    5. XM_030246038.1 → XP_030101898.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    6. XM_011249053.3 → XP_011247355.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011247355.1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    7. XM_011249051.2 → XP_011247353.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011247353.1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    8. XM_036156723.1 → XP_036012616.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    9. XM_011249054.4 → XP_011247356.1  BAH and coiled-coil domain-containing protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011247356.1

      UniProtKB/Swiss-Prot
      A2AS78, Q0KK52, Q0KK57, Q3TPP4, Q3UHG9, Q3UHR0, Q6GQV4, Q6P9S8, Q6PFC9, Q80UX2
      Related
      ENSMUSP00000112784.2, ENSMUST00000118987.2
      Conserved Domains (2) summary
      cd04714
      Location:2516 → 2635
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:1984 → 2036
      Tudor_3; DNA repair protein Crb2 Tudor domain

    10. XM_011249049.4 → XP_011247351.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011247351.1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    11. XM_011249050.4 → XP_011247352.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011247352.1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    12. XM_011249052.4 → XP_011247354.1  BAH and coiled-coil domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011247354.1

      Conserved Domains (2) summary
      cd04714
      Location:2517 → 2680
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cd20470
      Location:1975 → 2042
      Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

    RNA

    1. XR_001780012.2 RNA Sequence

    2. XR_003949454.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198423.4: Suppressed sequence

      Description
      NM_198423.4: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHR0.2 GenPept UniProtKB/Swiss-Prot:Q3UHR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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