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    Fam114a2 family with sequence similarity 114, member A2 [ Mus musculus (house mouse) ]

    Gene ID: 67726, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam114a2provided by MGI
    Official Full Name
    family with sequence similarity 114, member A2provided by MGI
    Primary source
    MGI:MGI:1917629
    See related
    Ensembl:ENSMUSG00000020523 AllianceGenome:MGI:1917629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810073G14Rik; 9030624B09Rik
    Summary
    Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human FAM114A2 (family with sequence similarity 114 member A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 12.4), whole brain E14.5 (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam114a2 in Genome Data Viewer
    Location:
    11 B1.3; 11 35.27 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57373816..57409482, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57482990..57518656, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 53706 Neighboring gene STARR-positive B cell enhancer ABC_E1825 Neighboring gene microfibrillar-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_29572 Neighboring gene predicted gene, 51895 Neighboring gene RIKEN cDNA 4933424L21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:57458544-57458653 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse. Khan A, et al. Reprod Biol, 2021 Sep. PMID 34315090
    2. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse.
      Title: The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM114A2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168667.1 → NP_001162138.1  protein FAM114A2 isoform 2

      See identical proteins and their annotated locations for NP_001162138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK149763, AL672236, BY134675
      Consensus CDS
      CCDS24717.1
      UniProtKB/Swiss-Prot
      Q8VE88
      Related
      ENSMUSP00000020831.7, ENSMUST00000020831.13
      Conserved Domains (1) summary
      pfam05334
      Location:70 → 236
      DUF719; Protein of unknown function (DUF719)

    2. NM_001168668.1 → NP_001162139.1  protein FAM114A2 isoform 1

      See identical proteins and their annotated locations for NP_001162139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL672236
      Consensus CDS
      CCDS48801.1
      UniProtKB/Swiss-Prot
      Q3UE42, Q5QNR1, Q8VE88, Q9D310
      Related
      ENSMUSP00000104478.2, ENSMUST00000108850.2
      Conserved Domains (2) summary
      pfam05334
      Location:77 → 243
      DUF719; Protein of unknown function (DUF719)
      pfam10310
      Location:4 → 99
      DUF5427; Family of unknown function (DUF5427)

    3. NM_026342.3 → NP_080618.1  protein FAM114A2 isoform 2

      See identical proteins and their annotated locations for NP_080618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK018570, AL672236, BY134675
      Consensus CDS
      CCDS24717.1
      UniProtKB/Swiss-Prot
      Q8VE88
      Conserved Domains (1) summary
      pfam05334
      Location:70 → 236
      DUF719; Protein of unknown function (DUF719)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      57373816..57409482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534016.3 → XP_006534079.1  protein FAM114A2 isoform X1

      See identical proteins and their annotated locations for XP_006534079.1

      UniProtKB/Swiss-Prot
      Q3UE42, Q5QNR1, Q8VE88, Q9D310
      Conserved Domains (2) summary
      pfam05334
      Location:77 → 243
      DUF719; Protein of unknown function (DUF719)
      pfam10310
      Location:4 → 99
      DUF5427; Family of unknown function (DUF5427)

    2. XM_011249195.4 → XP_011247497.1  protein FAM114A2 isoform X2

      See identical proteins and their annotated locations for XP_011247497.1

      UniProtKB/Swiss-Prot
      Q8VE88
      Conserved Domains (1) summary
      pfam05334
      Location:70 → 236
      DUF719; Protein of unknown function (DUF719)

    3. XM_011249194.4 → XP_011247496.1  protein FAM114A2 isoform X1

      See identical proteins and their annotated locations for XP_011247496.1

      UniProtKB/Swiss-Prot
      Q3UE42, Q5QNR1, Q8VE88, Q9D310
      Conserved Domains (2) summary
      pfam05334
      Location:77 → 243
      DUF719; Protein of unknown function (DUF719)
      pfam10310
      Location:4 → 99
      DUF5427; Family of unknown function (DUF5427)

    4. XM_036156918.1 → XP_036012811.1  protein FAM114A2 isoform X5

      Conserved Domains (2) summary
      pfam05334
      Location:78 → 244
      DUF719; Protein of unknown function (DUF719)
      pfam10310
      Location:10 → 100
      DUF5427; Family of unknown function (DUF5427)

    5. XM_006534013.4 → XP_006534076.1  protein FAM114A2 isoform X3

      Conserved Domains (2) summary
      pfam05334
      Location:85 → 251
      DUF719; Protein of unknown function (DUF719)
      pfam10310
      Location:12 → 107
      DUF5427; Family of unknown function (DUF5427)

    6. XM_030246250.2 → XP_030102110.1  protein FAM114A2 isoform X6

      Conserved Domains (1) summary
      pfam05334
      Location:77 → 243
      DUF719; Protein of unknown function (DUF719)

    7. XM_006534014.4 → XP_006534077.1  protein FAM114A2 isoform X4

      Conserved Domains (2) summary
      pfam05334
      Location:84 → 250
      DUF719; Protein of unknown function (DUF719)
      pfam10310
      Location:11 → 106
      DUF5427; Family of unknown function (DUF5427)

    RNA

    1. XR_004937011.1 RNA Sequence

    2. XR_001780047.1 RNA Sequence

    3. XR_003949494.1 RNA Sequence

    4. XR_004937010.1 RNA Sequence

    5. XR_004937009.1 RNA Sequence

    6. XR_004937008.1 RNA Sequence

    7. XR_879731.4 RNA Sequence

    8. XR_879730.4 RNA Sequence

    9. XR_001780046.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE88.2 GenPept UniProtKB/Swiss-Prot:Q8VE88

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