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    Papola poly (A) polymerase alpha [ Mus musculus (house mouse) ]

    Gene ID: 18789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Papolaprovided by MGI
    Official Full Name
    poly (A) polymerase alphaprovided by MGI
    Primary source
    MGI:MGI:109301
    See related
    Ensembl:ENSMUSG00000021111 AllianceGenome:MGI:109301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pap; Plap; PapIII
    Summary
    Enables poly(A) RNA polymerase activity. Acts upstream of or within cytosolic mRNA polyadenylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PAPOLA (poly(A) polymerase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.7), limb E14.5 (RPKM 31.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Papola in Genome Data Viewer
    Location:
    12 E; 12 56.06 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105750926..105805208)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105784677..105838949)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene GSK3B interacting protein Neighboring gene adenylate kinase 7 Neighboring gene STARR-seq mESC enhancer starr_33192 Neighboring gene STARR-seq mESC enhancer starr_33193 Neighboring gene STARR-seq mESC enhancer starr_33194 Neighboring gene STARR-seq mESC enhancer starr_33197 Neighboring gene predicted gene, 19554 Neighboring gene predicted gene, 32370 Neighboring gene STARR-seq mESC enhancer starr_33198 Neighboring gene VISTA enhancer mm1604 Neighboring gene STARR-positive B cell enhancer ABC_E7178 Neighboring gene STARR-positive B cell enhancer ABC_E3067 Neighboring gene vaccinia related kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP. Kashiwabara S, et al. Science, 2002 Dec 6. PMID 12471261
    2. Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Zhao W, et al. Mol Cell Biol, 1996 May. PMID 8628305, Free PMC Article
    3. Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I. Kim H, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716503
    4. ERK is a novel regulatory kinase for poly(A) polymerase. Lee SH, et al. Nucleic Acids Res, 2008 Feb. PMID 18084034, Free PMC Article
    5. Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. Kiefer H, et al. J Biol Chem, 2009 Apr 17. PMID 19224921, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cytosolic mRNA polyadenylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) polymerase alpha
    Names
    PAP-alpha
    polynucleotide adenylyltransferase
    NP_001334369.1
    NP_001409830.1
    NP_035242.1
    XP_006515655.1
    XP_006515656.1
    XP_006515657.1
    XP_006515658.1
    XP_006515659.1
    XP_017170481.1
    XP_017170483.1
    XP_030102471.1
    XP_030102472.1
    XP_030102473.1
    XP_036013145.1
    XP_036013146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347440.1 → NP_001334369.1  poly(A) polymerase alpha isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC158526, AK132704, BC060128, BU056874, BY308303, CF167932, CX200364
      Consensus CDS
      CCDS84000.1
      UniProtKB/TrEMBL
      E9PWC8, E9PZR3
      Related
      ENSMUSP00000126275.2, ENSMUST00000170002.8
      Conserved Domains (3) summary
      PRK12799
      Location:501 → 647
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:366 → 495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21 → 363
      PAP_central; Poly(A) polymerase central domain

    2. NM_001422901.1 → NP_001409830.1  poly(A) polymerase alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC144543, AC158526
      UniProtKB/TrEMBL
      F6VTN8

    3. NM_011112.4 → NP_035242.1  poly(A) polymerase alpha isoform 1

      See identical proteins and their annotated locations for NP_035242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158526, AK132704, BC060128, BU056874, BY308303, CX200364
      Consensus CDS
      CCDS49163.1
      UniProtKB/Swiss-Prot
      Q61183, Q61208, Q61209, Q8K4X2
      UniProtKB/TrEMBL
      Q3V141
      Related
      ENSMUSP00000105527.3, ENSMUST00000109901.9
      Conserved Domains (3) summary
      pfam04926
      Location:366 → 495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21 → 363
      PAP_central; Poly(A) polymerase central domain
      cl25496
      Location:530 → 725
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RNA

    1. NR_186615.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC144543, AC158526
      Related
      ENSMUST00000169938.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      105750926..105805208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314994.3 → XP_017170483.1  poly(A) polymerase alpha isoform X7

      UniProtKB/TrEMBL
      E9PWC8
      Conserved Domains (3) summary
      PRK12799
      Location:501 → 646
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:366 → 495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21 → 363
      PAP_central; Poly(A) polymerase central domain

    2. XM_017314992.3 → XP_017170481.1  poly(A) polymerase alpha isoform X2

      UniProtKB/TrEMBL
      Q3V141
      Conserved Domains (3) summary
      PRK12799
      Location:501 → 646
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:366 → 495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21 → 363
      PAP_central; Poly(A) polymerase central domain

    3. XM_036157252.1 → XP_036013145.1  poly(A) polymerase alpha isoform X11

      UniProtKB/TrEMBL
      F6VTN8
      Conserved Domains (3) summary
      PRK12799
      Location:251 → 397
      motB; flagellar motor protein MotB; Reviewed
      PTZ00418
      Location:1 → 317
      PTZ00418; Poly(A) polymerase; Provisional
      cl11966
      Location:1 → 113
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

    4. XM_030246613.1 → XP_030102473.1  poly(A) polymerase alpha isoform X12

      UniProtKB/TrEMBL
      F6VTN8
      Related
      ENSMUSP00000132353.2, ENSMUST00000166471.8
      Conserved Domains (2) summary
      PRK12799
      Location:205 → 345
      motB; flagellar motor protein MotB; Reviewed
      PTZ00418
      Location:2 → 265
      PTZ00418; Poly(A) polymerase; Provisional

    5. XM_036157253.1 → XP_036013146.1  poly(A) polymerase alpha isoform X13

      UniProtKB/TrEMBL
      F6VTN8
      Conserved Domains (2) summary
      PRK12799
      Location:205 → 345
      motB; flagellar motor protein MotB; Reviewed
      PTZ00418
      Location:2 → 265
      PTZ00418; Poly(A) polymerase; Provisional

    6. XM_006515596.4 → XP_006515659.1  poly(A) polymerase alpha isoform X9

      UniProtKB/TrEMBL
      Q3V141
      Conserved Domains (3) summary
      pfam05109
      Location:544 → 739
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam04926
      Location:380 → 509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35 → 377
      PAP_central; Poly(A) polymerase central domain

    7. XM_030246611.2 → XP_030102471.1  poly(A) polymerase alpha isoform X4

      UniProtKB/TrEMBL
      E9PWC8
      Conserved Domains (3) summary
      PRK12799
      Location:515 → 660
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:380 → 509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35 → 377
      PAP_central; Poly(A) polymerase central domain

    8. XM_006515594.4 → XP_006515657.1  poly(A) polymerase alpha isoform X5

      UniProtKB/TrEMBL
      E9QAN2
      Conserved Domains (3) summary
      PRK12799
      Location:515 → 661
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:380 → 509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35 → 377
      PAP_central; Poly(A) polymerase central domain

    9. XM_030246612.2 → XP_030102472.1  poly(A) polymerase alpha isoform X6

      UniProtKB/TrEMBL
      E9QAN2
      Conserved Domains (3) summary
      PRK12799
      Location:515 → 660
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:380 → 509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35 → 377
      PAP_central; Poly(A) polymerase central domain

    10. XM_006515593.5 → XP_006515656.1  poly(A) polymerase alpha isoform X3

      UniProtKB/TrEMBL
      E9PWC8
      Conserved Domains (3) summary
      PRK12799
      Location:515 → 661
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:380 → 509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35 → 377
      PAP_central; Poly(A) polymerase central domain

    11. XM_006515592.4 → XP_006515655.1  poly(A) polymerase alpha isoform X1

      UniProtKB/TrEMBL
      Q3V141
      Conserved Domains (3) summary
      PRK12799
      Location:515 → 660
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:380 → 509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35 → 377
      PAP_central; Poly(A) polymerase central domain

    12. XM_006515595.4 → XP_006515658.1  poly(A) polymerase alpha isoform X8

      UniProtKB/TrEMBL
      E9QAN2
      Conserved Domains (3) summary
      PRK12799
      Location:515 → 661
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:380 → 509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35 → 377
      PAP_central; Poly(A) polymerase central domain

    RNA

    1. XR_003949999.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61183.4 GenPept UniProtKB/Swiss-Prot:Q61183

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