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    Usp54 ubiquitin specific peptidase 54 [ Mus musculus (house mouse) ]

    Gene ID: 78787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp54provided by MGI
    Official Full Name
    ubiquitin specific peptidase 54provided by MGI
    Primary source
    MGI:MGI:1926037
    See related
    Ensembl:ENSMUSG00000034235 AllianceGenome:MGI:1926037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930429G18Rik; C030002J06Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Orthologous to human USP54 (ubiquitin specific peptidase 54). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.3), cortex adult (RPKM 4.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Usp54 in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20598980..20694559, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20548912..20644491, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene MSS51 mitochondrial translational activator Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene protein phosphatase 3, catalytic subunit, beta isoform Neighboring gene RIKEN cDNA 1810062O18 gene Neighboring gene STARR-positive B cell enhancer ABC_E11565 Neighboring gene STARR-positive B cell enhancer ABC_E7297 Neighboring gene myozenin 1 Neighboring gene synaptopodin 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis. Fraile JM, et al. Oncotarget, 2016 Nov 15. PMID 27769071, Free PMC Article
    2. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 54; inactive ubiquitin carboxyl-terminal hydrolase 54
    Names
    inactive ubiquitin-specific peptidase 54
    ubiquitin specific protease 54
    NP_001390006.1
    NP_001390007.1
    NP_001390008.1
    NP_001390009.1
    NP_001390010.1
    NP_084456.2
    XP_036014801.1
    XP_036014802.1
    XP_036014803.1
    XP_036014804.1
    XP_036014805.1
    XP_036014806.1
    XP_036014808.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403077.1 → NP_001390006.1  ubiquitin carboxyl-terminal hydrolase 54 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC146594

    2. NM_001403078.1 → NP_001390007.1  ubiquitin carboxyl-terminal hydrolase 54 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC146594
      UniProtKB/Swiss-Prot
      Q149D8, Q149D9, Q6NZE1, Q8BL06, Q8BZ28, Q9D2I9
      Related
      ENSMUSP00000022356.5, ENSMUST00000022356.12

    3. NM_001403079.1 → NP_001390008.1  ubiquitin carboxyl-terminal hydrolase 54 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC146594

    4. NM_001403080.1 → NP_001390009.1  ubiquitin carboxyl-terminal hydrolase 54 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC146594

    5. NM_001403081.1 → NP_001390010.1  ubiquitin carboxyl-terminal hydrolase 54 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC146594

    6. NM_030180.3 → NP_084456.2  ubiquitin carboxyl-terminal hydrolase 54 isoform 1

      See identical proteins and their annotated locations for NP_084456.2

      Status: VALIDATED

      Source sequence(s)
      AC146594
      Consensus CDS
      CCDS26847.2
      UniProtKB/Swiss-Prot
      Q149D8, Q149D9, Q6NZE1, Q8BL06, Q8BZ28, Q9D2I9
      Related
      ENSMUSP00000036214.8, ENSMUST00000035340.14
      Conserved Domains (1) summary
      pfam00443
      Location:32 → 349
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RNA

    1. NR_175348.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC146594

    2. NR_175349.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC146594

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20598980..20694559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158911.1 → XP_036014804.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X3

      Conserved Domains (1) summary
      pfam00443
      Location:32 → 349
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_036158913.1 → XP_036014806.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X6

      Conserved Domains (1) summary
      pfam00443
      Location:32 → 349
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_036158908.1 → XP_036014801.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:32 → 349
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. XM_036158915.1 → XP_036014808.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X9

    5. XM_036158910.1 → XP_036014803.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:32 → 349
      UCH; Ubiquitin carboxyl-terminal hydrolase

    6. XM_036158909.1 → XP_036014802.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:32 → 349
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. XM_036158912.1 → XP_036014805.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X5

      Conserved Domains (1) summary
      cd02257
      Location:12 → 220
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RNA

    1. XR_001781171.2 RNA Sequence

    2. XR_001781170.2 RNA Sequence

    3. XR_004938462.1 RNA Sequence

    4. XR_004938461.1 RNA Sequence

    5. XR_001781172.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BL06.2 GenPept UniProtKB/Swiss-Prot:Q8BL06

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