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    Cadm2 cell adhesion molecule 2 [ Mus musculus (house mouse) ]

    Gene ID: 239857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cadm2provided by MGI
    Official Full Name
    cell adhesion molecule 2provided by MGI
    Primary source
    MGI:MGI:2442722
    See related
    Ensembl:ENSMUSG00000064115 AllianceGenome:MGI:2442722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NECL3; Igdf4d; Igsf4d; SynCAM2; SynCAM 2; 9330131D06; 2900078E11Rik; A830029E02Rik
    Summary
    Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in axon. Predicted to be active in neuronal cell body membrane. Is expressed in bone; central nervous system; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 12.4), cortex adult (RPKM 11.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cadm2 in Genome Data Viewer
    Location:
    16 C1.3- C2; 16 37.96 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (66452302..67417825, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (66655416..67620917, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22448 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41177 Neighboring gene STARR-seq mESC enhancer starr_41178 Neighboring gene STARR-seq mESC enhancer starr_41179 Neighboring gene STARR-seq mESC enhancer starr_41180 Neighboring gene RIKEN cDNA 1700010K23 gene Neighboring gene STARR-seq mESC enhancer starr_41181 Neighboring gene STARR-seq mESC enhancer starr_41182 Neighboring gene predicted gene, 57633 Neighboring gene STARR-seq mESC enhancer starr_41183 Neighboring gene STARR-seq mESC enhancer starr_41184 Neighboring gene STARR-seq mESC enhancer starr_41185 Neighboring gene STARR-seq mESC enhancer starr_41186 Neighboring gene STARR-seq mESC enhancer starr_41187 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41188 Neighboring gene STARR-seq mESC enhancer starr_41189 Neighboring gene predicted gene, 24681

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Necl2/3-mediated mechanism for tripartite synapse formation. Nozawa O, et al. Development, 2023 Feb 15. PMID 36458527
    2. Cadm2 regulates body weight and energy homeostasis in mice. Yan X, et al. Mol Metab, 2018 Feb. PMID 29217450, Free PMC Article
    3. CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Sanchez-Roige S, et al. Transl Psychiatry, 2023 May 12. PMID 37173343, Free PMC Article
    4. Differential Contribution of Cadm1-Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons. Sukhanov N, et al. J Neurosci, 2021 Feb 17. PMID 33397712, Free PMC Article
    5. Axoglial Adhesion by Cadm4 Regulates CNS Myelination. Elazar N, et al. Neuron, 2019 Jan 16. PMID 30551998, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.
      Title: CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.
    2. Cadm2 expression regulates body weight and glucose homeostasis.
      Title: Cadm2 regulates body weight and energy homeostasis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell adhesion molecule 2
    Names
    NECL-3
    immunoglobulin superfamily member 4D
    immunoglobulin superfamily, member 4
    nectin-like protein 3
    synaptic cell adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145977.1 → NP_001139449.1  cell adhesion molecule 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001139449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) missing a 9 aa segment compared to isoform 1.
      Source sequence(s)
      AK033973, AK043760, AK165030, BB667048, BF458515, CT010571
      Consensus CDS
      CCDS49885.1
      UniProtKB/TrEMBL
      G3UZM4
      Related
      ENSMUSP00000113178.2, ENSMUST00000120898.8
      Conserved Domains (4) summary
      smart00294
      Location:348 → 366
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:240 → 303
      IGc2; Immunoglobulin C-2 Type
      cd05884
      Location:141 → 223
      Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cd07701
      Location:26 → 120
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

    2. NM_001347247.1 → NP_001334176.1  cell adhesion molecule 2 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region and contains an exon in the 3' coding region compared to variant 1. The encoded isoform (3) is longer than isoform 1.
      Source sequence(s)
      AC105980, AC109233, AC154196, AC154428, CJ259603, CT010571
      Consensus CDS
      CCDS84251.1
      UniProtKB/Swiss-Prot
      B1B1A5, B1B1A6, B2RTL0, Q8BLQ9, Q8BXJ7, Q8BYP1, Q8BZP4
      UniProtKB/TrEMBL
      G3UZM4
      Related
      ENSMUSP00000113500.2, ENSMUST00000120594.8
      Conserved Domains (4) summary
      smart00294
      Location:388 → 406
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:240 → 303
      IGc2; Immunoglobulin C-2 Type
      cd05884
      Location:141 → 223
      Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cd07701
      Location:26 → 120
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

    3. NM_178721.4 → NP_848836.2  cell adhesion molecule 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_848836.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK043760, AK165030, BB667048, BF458515, CT010571
      Consensus CDS
      CCDS28270.1
      UniProtKB/TrEMBL
      G3UZM4
      Related
      ENSMUSP00000109931.2, ENSMUST00000114292.8
      Conserved Domains (5) summary
      smart00294
      Location:357 → 375
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:249 → 312
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:251 → 260
      Ig; Ig strand B [structural motif]
      cd05884
      Location:129 → 232
      IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
      cd07701
      Location:35 → 130
      IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      66452302..67417825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523026.5 → XP_006523089.1  cell adhesion molecule 2 isoform X2

      UniProtKB/TrEMBL
      G3UZM4
      Related
      ENSMUSP00000134554.2, ENSMUST00000128168.3
      Conserved Domains (4) summary
      smart00294
      Location:397 → 415
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:249 → 312
      IGc2; Immunoglobulin C-2 Type
      cd05884
      Location:150 → 232
      Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cd07701
      Location:35 → 129
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

    2. XM_011246129.4 → XP_011244431.1  cell adhesion molecule 2 isoform X4

      UniProtKB/TrEMBL
      G3UZM4
      Conserved Domains (5) summary
      smart00294
      Location:371 → 389
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:263 → 326
      IGc2; Immunoglobulin C-2 Type
      cd05884
      Location:164 → 246
      Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cd07701
      Location:49 → 143
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cl29795
      Location:9 → 56
      MtrA; Tetrahydromethanopterin S-methyltransferase, subunit A

    3. XM_011246128.4 → XP_011244430.1  cell adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      G3UZM4
      Conserved Domains (5) summary
      smart00294
      Location:411 → 429
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:263 → 326
      IGc2; Immunoglobulin C-2 Type
      cd05884
      Location:164 → 246
      Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cd07701
      Location:49 → 143
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cl29795
      Location:9 → 56
      MtrA; Tetrahydromethanopterin S-methyltransferase, subunit A

    4. XM_036159925.1 → XP_036015818.1  cell adhesion molecule 2 isoform X6

      Conserved Domains (4) summary
      smart00294
      Location:280 → 298
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:132 → 195
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:134 → 143
      Ig; Ig strand B [structural motif]
      cd05884
      Location:12 → 115
      IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

    5. XM_036159924.1 → XP_036015817.1  cell adhesion molecule 2 isoform X5

      UniProtKB/TrEMBL
      G3UZM4
      Conserved Domains (5) summary
      smart00294
      Location:353 → 371
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:245 → 308
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:247 → 256
      Ig; Ig strand B [structural motif]
      cd05884
      Location:125 → 228
      IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
      cd07701
      Location:31 → 126
      IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains

    6. XM_036159927.1 → XP_036015820.1  cell adhesion molecule 2 isoform X7

      Conserved Domains (4) summary
      smart00294
      Location:240 → 258
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:132 → 195
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:134 → 143
      Ig; Ig strand B [structural motif]
      cd05884
      Location:12 → 115
      IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

    7. XM_036159926.1 → XP_036015819.1  cell adhesion molecule 2 isoform X6

      Conserved Domains (4) summary
      smart00294
      Location:280 → 298
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:132 → 195
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:134 → 143
      Ig; Ig strand B [structural motif]
      cd05884
      Location:12 → 115
      IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

    8. XM_036159923.1 → XP_036015816.1  cell adhesion molecule 2 isoform X3

      UniProtKB/TrEMBL
      G3UZM4
      Conserved Domains (5) summary
      smart00294
      Location:393 → 411
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:245 → 308
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:247 → 256
      Ig; Ig strand B [structural motif]
      cd05884
      Location:125 → 228
      IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
      cd07701
      Location:31 → 126
      IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains

    RNA

    1. XR_001781826.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLQ9.2 GenPept UniProtKB/Swiss-Prot:Q8BLQ9

    Gene LinkOut

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