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    Mrpl14 mitochondrial ribosomal protein L14 [ Mus musculus (house mouse) ]

    Gene ID: 68463, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrpl14provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L14provided by MGI
    Primary source
    MGI:MGI:1333864
    See related
    Ensembl:ENSMUSG00000023939 AllianceGenome:MGI:1333864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpml32; MRP-L32; 1110006I11Rik
    Summary
    Predicted to be a structural constituent of ribosome. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL14 (mitochondrial ribosomal protein L14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 36.7), stomach adult (RPKM 34.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl14 in Genome Data Viewer
    Location:
    17 C; 17 22.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45991689..46009421)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45685722..45698495)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52283 Neighboring gene STARR-positive B cell enhancer ABC_E9955 Neighboring gene predicted gene, 25008 Neighboring gene STARR-positive B cell enhancer ABC_E10956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45775877-45776144 Neighboring gene calpain 11 Neighboring gene transmembrane protein 63b Neighboring gene STARR-positive B cell enhancer ABC_E7534 Neighboring gene predicted gene, 35456 Neighboring gene RIKEN cDNA 1600014C23 gene Neighboring gene cDNA sequence BE949265

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Roth KA, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618441, Free PMC Article
    2. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL14m
    Names
    39S ribosomal protein L14, mitochondrial
    L14mt
    MRP-L14
    mitochondrial ribosomal protein L32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026732.3 → NP_081008.1  large ribosomal subunit protein uL14m precursor

      See identical proteins and their annotated locations for NP_081008.1

      Status: VALIDATED

      Source sequence(s)
      AI844611, AK050273, BY085715
      Consensus CDS
      CCDS28815.1
      UniProtKB/Swiss-Prot
      Q3UNL3, Q9D1I6
      Related
      ENSMUSP00000024734.8, ENSMUST00000024734.8
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      45991689..46009421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524843.4 → XP_006524906.1  large ribosomal subunit protein uL14m isoform X1

      See identical proteins and their annotated locations for XP_006524906.1

      UniProtKB/Swiss-Prot
      Q3UNL3, Q9D1I6
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e

    2. XM_006524844.5 → XP_006524907.1  large ribosomal subunit protein uL14m isoform X1

      See identical proteins and their annotated locations for XP_006524907.1

      UniProtKB/Swiss-Prot
      Q3UNL3, Q9D1I6
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e

    3. XM_017317618.3 → XP_017173107.1  large ribosomal subunit protein uL14m isoform X2

      Conserved Domains (1) summary
      cl00328
      Location:2 → 108
      Ribosomal_L14; Ribosomal protein L14p/L23e
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1I6.1 GenPept UniProtKB/Swiss-Prot:Q9D1I6

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