Lims2 LIM and senescent cell antigen like domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lims2provided by MGI
Official Full Name: LIM and senescent cell antigen like domains 2provided by MGI
Primary source: MGI:MGI:2385067
See related: Ensembl:ENSMUSG00000024395 AllianceGenome:MGI:2385067
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PINCH2
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including cell-cell junction organization; negative regulation of cell population proliferation; and positive regulation of integrin-mediated signaling pathway. Located in focal adhesion. Is expressed in several structures, including bladder; early conceptus; nervous system; oocyte; and urethra of male. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to human LIMS2 (LIM zinc finger domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 69.7), lung adult (RPKM 57.8) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 17.89 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (32055346..32091673)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (31922293..31958620)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Requirement for PINCH in skeletal myoblast differentiation.
Title: Requirement for PINCH in skeletal myoblast differentiation.
Fluid shear stress modulates endothelial inflammation by targeting LIMS2.
Title: Fluid shear stress modulates endothelial inflammation by targeting LIMS2.
Let-7g controls the motility of mouse myoblasts in cell culture by post-transcriptionally regulating the expression of Pinch-2.
Title: MiRNA let-7g regulates skeletal myoblast motility via Pinch-2.
Rsu-1 expression is dramatically decreased in PINCH double knockout mouse livers.
Title: Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.
Absence of either PINCH1 or PINCH2 in myocardium leads to exacerbated cardiac injury and deterioration in cardiac function after myocardial infarction.
Title: Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.
LIM1 domain only of either PINCH1 or PINCH2 can prevent ILK degradation despite their failure to localize to focal adhesions.
Title: Consequences of loss of PINCH2 expression in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78384 (e-PCR)
- UniSTS:47022

AI853548 (e-PCR)
- UniSTS:166089

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell junction organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cholangiocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of integrin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cholangiocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of hepatocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neural precursor cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neural precursor cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LIM and senescent cell antigen-like-containing domain protein 2

Names: particularly interesting new Cys-His protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365015.1 → NP_001351944.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC131761

Conserved Domains (5) summary

cd09331
Location:10 → 68

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:71 → 122

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:135 → 185

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:191 → 244

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:252 → 305

LIM5_PINCH; The fifth LIM domain of protein PINCH
NM_001379137.1 → NP_001366066.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC131761

Conserved Domains (5) summary

cd09331
Location:15 → 73

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:76 → 127

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:140 → 190

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:196 → 249

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:257 → 310

LIM5_PINCH; The fifth LIM domain of protein PINCH
NM_001379138.1 → NP_001366067.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC131761

Conserved Domains (5) summary

cd09331
Location:10 → 68

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:71 → 122

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:135 → 185

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:191 → 244

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:252 → 305

LIM5_PINCH; The fifth LIM domain of protein PINCH
NM_144862.4 → NP_659111.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 1

See identical proteins and their annotated locations for NP_659111.1

Status: VALIDATED

Source sequence(s)

AC131761

Consensus CDS

CCDS29113.1

UniProtKB/Swiss-Prot

Q91XD2

Related

ENSMUSP00000025254.8, ENSMUST00000025254.9

Conserved Domains (5) summary

cd09331
Location:15 → 73

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:76 → 127

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:140 → 190

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:196 → 249

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:257 → 310

LIM5_PINCH; The fifth LIM domain of protein PINCH

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

32055346..32091673

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161102.1 → XP_036016995.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform X1

Conserved Domains (3) summary

cd09333
Location:84 → 134

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:140 → 193

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:201 → 254

LIM5_PINCH; The fifth LIM domain of protein PINCH
XM_036161103.1 → XP_036016996.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform X2

UniProtKB/TrEMBL

A0A286YCS7

Related

ENSMUSP00000153122.2, ENSMUST00000223753.2

Conserved Domains (2) summary

cd09335
Location:161 → 214

LIM5_PINCH; The fifth LIM domain of protein PINCH

cl02475
Location:117 → 153

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers