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    Macrod1 mono-ADP ribosylhydrolase 1 [ Mus musculus (house mouse) ]

    Gene ID: 107227, updated on 27-Nov-2024

    Summary

    Official Symbol
    Macrod1provided by MGI
    Official Full Name
    mono-ADP ribosylhydrolase 1provided by MGI
    Primary source
    MGI:MGI:2147583
    See related
    Ensembl:ENSMUSG00000036278 AllianceGenome:MGI:2147583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrp16; D930010J01Rik
    Summary
    Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in mitochondrion. Orthologous to human MACROD1 (mono-ADP ribosylhydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 26.0), adrenal adult (RPKM 22.0) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Macrod1 in Genome Data Viewer
    Location:
    19 A; 19 5.17 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7034065..7175427)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7056728..7198062)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tRNA phosphotransferase 1 Neighboring gene fermitin family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052 Neighboring gene STARR-seq mESC enhancer starr_45447 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_45448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7140992-7141179 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7190709-7190892 Neighboring gene predicted gene, 38621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7238874-7239062 Neighboring gene STARR-positive B cell enhancer ABC_E8735 Neighboring gene OTU domain, ubiquitin aldehyde binding 1 Neighboring gene cytochrome c oxidase subunit 8A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP-ribosylglutamate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ADP-ribosylglutamate hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ADP-ribosylglutamate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables O-acetyl-ADP-ribose deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity, acting on glycosyl bonds ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity, acting on glycosyl bonds ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-glutamate ADP-deribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-glutamate ADP-deribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein de-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein de-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in purine nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purine nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ADP-ribose glycohydrolase MACROD1
    Names
    MACRO domain containing 1
    MACRO domain-containing protein 1
    O-acetyl-ADP-ribose deacetylase MACROD1
    [Protein ADP-ribosylaspartate] hydrolase MACROD1
    [Protein ADP-ribosylglutamate] hydrolase
    [Protein ADP-ribosylglutamate] hydrolase MACROD1
    NP_001365848.1
    NP_001365849.1
    NP_001390467.1
    NP_001390469.1
    NP_598908.2
    XP_006526626.1
    XP_036017267.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378919.1NP_001365848.1  ADP-ribose glycohydrolase MACROD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109619, AC140307
      Conserved Domains (1) summary
      cd02908
      Location:151317
      Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
    2. NM_001378920.1NP_001365849.1  ADP-ribose glycohydrolase MACROD1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109619
      Conserved Domains (1) summary
      cl00019
      Location:151170
      Macro_SF; macrodomain superfamily
    3. NM_001403538.1NP_001390467.1  ADP-ribose glycohydrolase MACROD1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109619, AC140307
    4. NM_001403540.1NP_001390469.1  ADP-ribose glycohydrolase MACROD1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109619, AC140307
    5. NM_134147.5NP_598908.2  ADP-ribose glycohydrolase MACROD1 isoform 1

      See identical proteins and their annotated locations for NP_598908.2

      Status: VALIDATED

      Source sequence(s)
      AC109619, AC140307
      Consensus CDS
      CCDS50376.1
      UniProtKB/Swiss-Prot
      Q922B1
      Related
      ENSMUSP00000039507.6, ENSMUST00000040261.7
      Conserved Domains (2) summary
      COG2110
      Location:150314
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd02908
      Location:151317
      Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7034065..7175427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161374.1XP_036017267.1  ADP-ribose glycohydrolase MACROD1 isoform X1

      Conserved Domains (1) summary
      cd02908
      Location:151317
      Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
    2. XM_006526563.4XP_006526626.1  ADP-ribose glycohydrolase MACROD1 isoform X2

      Conserved Domains (1) summary
      cl00019
      Location:149306
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...