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    Atosb atos homolog B [ Mus musculus (house mouse) ]

    Gene ID: 230088, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atosbprovided by MGI
    Official Full Name
    atos homolog Bprovided by MGI
    Primary source
    MGI:MGI:2441854
    See related
    Ensembl:ENSMUSG00000036002 AllianceGenome:MGI:2441854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam214b; B230312A22Rik
    Summary
    Predicted to be located in nucleus. Orthologous to human ATOSB (atos homolog B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 19.2), small intestine adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atosb in Genome Data Viewer
    Location:
    4 A5; 4 22.99 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43032414..43046220, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43032414..43046220, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6165 Neighboring gene STARR-positive B cell enhancer ABC_E1642 Neighboring gene STARR-positive B cell enhancer ABC_E9237 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O Neighboring gene STARR-positive B cell enhancer ABC_E6166 Neighboring gene stomatin (Epb7.2)-like 2 Neighboring gene STARR-seq mESC enhancer starr_10046 Neighboring gene unc-13 homolog B Neighboring gene STARR-seq mESC enhancer starr_10047 Neighboring gene predicted gene, 23709 Neighboring gene predicted gene, 25010

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome. Werren EA, et al. Nat Commun, 2024 Feb 22. PMID 38388531, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA1539

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    atos homolog protein B
    Names
    family with sequence similarity 214, member B
    protein FAM214B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253353.1 → NP_001240282.1  atos homolog protein B

      See identical proteins and their annotated locations for NP_001240282.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK149610, AL672276, BQ175731
      Consensus CDS
      CCDS18090.1
      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Related
      ENSMUSP00000103592.2, ENSMUST00000107958.8
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    2. NM_001253354.1 → NP_001240283.1  atos homolog protein B

      See identical proteins and their annotated locations for NP_001240283.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL672276, BC046771
      Consensus CDS
      CCDS18090.1
      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Related
      ENSMUSP00000103593.2, ENSMUST00000107959.8
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    3. NM_172691.3 → NP_766279.1  atos homolog protein B

      See identical proteins and their annotated locations for NP_766279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK045811, BQ175731, BU702672
      Consensus CDS
      CCDS18090.1
      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Related
      ENSMUSP00000038177.6, ENSMUST00000036462.12
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    RNA

    1. NR_045567.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an internal exon, compare to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC054736
      Related
      ENSMUST00000135067.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43032414..43046220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537824.1 → XP_006537887.1  atos homolog protein B isoform X1

      See identical proteins and their annotated locations for XP_006537887.1

      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Related
      ENSMUSP00000103591.2, ENSMUST00000107957.8
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    2. XM_011249994.2 → XP_011248296.1  atos homolog protein B isoform X1

      See identical proteins and their annotated locations for XP_011248296.1

      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Related
      ENSMUSP00000103590.2, ENSMUST00000107956.8
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    3. XM_030253415.1 → XP_030109275.1  atos homolog protein B isoform X2

      Conserved Domains (2) summary
      pfam13889
      Location:479 → 535
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:347 → 397
      DUF4210; Domain of unknown function (DUF4210)

    4. XM_006537822.3 → XP_006537885.1  atos homolog protein B isoform X1

      See identical proteins and their annotated locations for XP_006537885.1

      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    5. XM_030253413.2 → XP_030109273.1  atos homolog protein B isoform X2

      Conserved Domains (2) summary
      pfam13889
      Location:479 → 535
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:347 → 397
      DUF4210; Domain of unknown function (DUF4210)

    6. XM_030253416.2 → XP_030109276.1  atos homolog protein B isoform X2

      Conserved Domains (2) summary
      pfam13889
      Location:479 → 535
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:347 → 397
      DUF4210; Domain of unknown function (DUF4210)

    7. XM_030253414.2 → XP_030109274.1  atos homolog protein B isoform X2

      Conserved Domains (2) summary
      pfam13889
      Location:479 → 535
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:347 → 397
      DUF4210; Domain of unknown function (DUF4210)

    8. XM_006537823.4 → XP_006537886.1  atos homolog protein B isoform X1

      See identical proteins and their annotated locations for XP_006537886.1

      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    9. XM_017320125.3 → XP_017175614.1  atos homolog protein B isoform X1

      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)

    10. XM_030253412.2 → XP_030109272.1  atos homolog protein B isoform X1

      UniProtKB/Swiss-Prot
      B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
      Conserved Domains (2) summary
      pfam13889
      Location:480 → 536
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:348 → 398
      DUF4210; Domain of unknown function (DUF4210)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BR27.1 GenPept UniProtKB/Swiss-Prot:Q8BR27

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