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    Lzic leucine zipper and CTNNBIP1 domain containing [ Mus musculus (house mouse) ]

    Gene ID: 69151, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lzicprovided by MGI
    Official Full Name
    leucine zipper and CTNNBIP1 domain containingprovided by MGI
    Primary source
    MGI:MGI:1916401
    See related
    Ensembl:ENSMUSG00000028990 AllianceGenome:MGI:1916401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810030J04Rik
    Summary
    Predicted to enable beta-catenin binding activity. Orthologous to human LZIC (leucine zipper and CTNNBIP1 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.1), limb E14.5 (RPKM 10.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lzic in Genome Data Viewer
    Location:
    4 E2; 4 79.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149569642..149581952)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149485185..149503516)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 11-2, pseudogene 2 Neighboring gene retinol binding protein 7, cellular Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_12115 Neighboring gene transmembrame protein 274 Neighboring gene STARR-seq mESC enhancer starr_12116 Neighboring gene STARR-positive B cell enhancer mm9_chr4:148891953-148892254 Neighboring gene catenin beta interacting protein 1 Neighboring gene predicted gene, 24381 Neighboring gene microRNA 5616

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LZIC regulates neuronal survival during zebrafish development. Clements WK, et al. Dev Biol, 2005 Jul 15. PMID 15932753
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein LZIC
    Names
    leucine zipper and CTNNBIP1 domain-containing protein
    leucine zipper and ICAT homologous domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356322.1 → NP_001343251.1  protein LZIC

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK146824, AW047580, BY146654, CN455726
      Consensus CDS
      CCDS18961.1
      UniProtKB/Swiss-Prot
      Q8K3C3, Q9D8V3
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT

    2. NM_026963.6 → NP_081239.1  protein LZIC

      See identical proteins and their annotated locations for NP_081239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK146824, AW047580
      Consensus CDS
      CCDS18961.1
      UniProtKB/Swiss-Prot
      Q8K3C3, Q9D8V3
      Related
      ENSMUSP00000030842.8, ENSMUST00000030842.8
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149569642..149581952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253760.2 → XP_030109620.1  protein LZIC isoform X1

      Conserved Domains (1) summary
      pfam06384
      Location:139 → 214
      ICAT; Beta-catenin-interacting protein ICAT

    2. XM_030253762.2 → XP_030109622.1  protein LZIC isoform X2

      UniProtKB/Swiss-Prot
      Q8K3C3, Q9D8V3
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT

    3. XM_036164403.1 → XP_036020296.1  protein LZIC isoform X2

      UniProtKB/Swiss-Prot
      Q8K3C3, Q9D8V3
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT

    4. XM_030253763.2 → XP_030109623.1  protein LZIC isoform X2

      UniProtKB/Swiss-Prot
      Q8K3C3, Q9D8V3
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT

    5. XM_017320382.3 → XP_017175871.1  protein LZIC isoform X2

      UniProtKB/Swiss-Prot
      Q8K3C3, Q9D8V3
      Conserved Domains (1) summary
      pfam06384
      Location:113 → 188
      ICAT; Beta-catenin-interacting protein ICAT
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3C3.1 GenPept UniProtKB/Swiss-Prot:Q8K3C3

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